About: Molecular characterization and biological activity of bovine interferon-omega3

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About: Molecular characterization and biological activity of bovine interferon-omega3 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular characterization and biological activity of bovine interferon-omega3
Creator	Liu, Ying Bao, Jun Wang, Junwei An, Dong Gao, Mingchun Guo, Yongli Luo, Xiuxin Ma, Bo
Source	Elsevier; Medline; PMC
abstract	Abstract Bovine interferon-omega3 (BoIFN-ω3) gene was amplified from bovine liver genomic DNA, which encodes a 195-amino acid protein containing a 23-amino acid signal peptide. Analysis of the molecular characteristics revealed that BoIFN-ω3 evolving from IFN-ω, contained four cysteine residues and five alpha helices, showing that BoIFN-ω3 presented the typical molecular characteristics of type I interferon. BoIFN-ω3 exhibited antiviral and antiproliferative activities, which exerted a protective effect against VSV in several mammalian cell lines, as well as against BEV, IBRV, and BVDV in MDBK cell. Moreover, BoIFN-ω3 was shown to be highly sensitive to trypsin, but remaining stable despite changes in pH and temperature. Additionally, BoIFN-ω3 induced the transcription of Mx1, ISG15, and ISG56 genes, as well as the expression of Mx1 protein in a time-dependent manner. These findings will be useful to further study BoIFN-ω in host's defence against infectious diseases, particularly viral infections. Furthermore, results will facilitate further research on the bovine interferon family.
has issue date	2017-12-31(xsd:dateTime)
bibo:doi	10.1016/j.rvsc.2017.01.028
bibo:pmid	28254416
has license	els-covid
sha1sum (hex)	a4a52942b78204063e7a26124ee51bed61dc4f03
schema:url	https://doi.org/10.1016/j.rvsc.2017.01.028
resource representing a document's title	Molecular characterization and biological activity of bovine interferon-omega3
has PubMed Central identifier	PMC7127041
has PubMed identifier	28254416
schema:publication	Research in Veterinary Science
resource representing a document's body	covid:a4a52942b78204063e7a26124ee51bed61dc4f03#body_text
is schema:about of	named entity 'VSV' named entity 'encodes' named entity 'protein' named entity 'molecular' named entity 'manner' named entity 'acid' named entity 'bovine' covid:arg/a4a52942b78204063e7a26124ee51bed61dc4f03 named entity 'TRYPSIN' named entity 'PROTECTIVE EFFECT' named entity '27S' named entity 'BUT' named entity 'INFECTIOUS DISEASES' named entity 'MOLECULAR' named entity 'ANTIPROLIFERATIVE' named entity 'TYPE I INTERFERON' named entity 'GENES' named entity 'ALPHA' named entity 'MX1' named entity 'GENE' named entity 'FINDINGS' named entity 'A 195' named entity 'STUDY' named entity 'TRANSCRIPTION' named entity 'CONTAINING' named entity 'THESE' named entity 'BEV' named entity 'USEFUL' named entity 'MDBK CELL' named entity 'CHANGES' named entity 'PRESENTED' named entity 'AMPLIFIED' named entity 'EXPRESSION' named entity 'ANALYSIS' named entity 'INTERFERON' named entity 'EVOLVING' named entity 'CHARACTERISTICS' named entity 'GENOMIC DNA' named entity 'VSV' named entity 'MOLECULAR' named entity 'PROTEIN ' named entity 'INTERFERON' named entity 'BOVINE' named entity 'BIOLOGICAL ACTIVITY' named entity 'MAMMALIAN CELL' named entity 'REVEALED' named entity 'AMINO ACID PROTEIN' named entity 'HOST' named entity 'EXERTED' named entity 'CHARACTERIZATION' named entity 'FAMILY' named entity 'BOVINE' named entity 'ANTIVIRAL' named entity 'STABLE' named entity 'IFN' named entity 'AMINO ACID' named entity 'CYSTEINE' named entity 'CELL LINES' named entity 'HIGHLY SENSITIVE' named entity 'SIGNAL PEPTIDE' named entity 'TIME' named entity 'ISG15' named entity 'DEPENDENT' named entity 'BVDV' named entity 'RESULTS' named entity 'ISG56' named entity 'ACTIVITIES' named entity 'VIRAL INFECTIONS' named entity 'REMAINING' named entity 'TYPICAL' named entity 'INDUCED' named entity 'RESEARCH' named entity 'SENSITIVE TO' named entity 'LIVER'

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