About: Computational analysis of interactomes: Current and future perspectives for bioinformatics approaches to model the host

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About: Computational analysis of interactomes: Current and future perspectives for bioinformatics approaches to model the host–pathogen interaction space Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Computational analysis of interactomes: Current and future perspectives for bioinformatics approaches to model the host–pathogen interaction space
Creator	Arnold, Roland Boonen, Kurt Kim, Philip Sun, Mark
source	Elsevier; Medline; PMC
abstract	Abstract Bacterial and viral pathogens affect their eukaryotic host partly by interacting with proteins of the host cell. Hence, to investigate infection from a systems’ perspective we need to construct complete and accurate host–pathogen protein–protein interaction networks. Because of the paucity of available data and the cost associated with experimental approaches, any construction and analysis of such a network in the near future has to rely on computational predictions. Specifically, this challenge consists of a number of sub-problems: First, prediction of possible pathogen interactors (e.g. effector proteins) is necessary for bacteria and protozoa. Second, the prospective host binding partners have to be determined and finally, the impact on the host cell analyzed. This review gives an overview of current bioinformatics approaches to obtain and understand host–pathogen interactions. As an application example of the methods covered, we predict host–pathogen interactions of Salmonella and discuss the value of these predictions as a prospective for further research.
has issue date	2012-08-31(xsd:dateTime)
bibo:doi	10.1016/j.ymeth.2012.06.011
bibo:pmid	22750305
has license	els-covid
sha1sum (hex)	a46461d35067bed17057cda849bf940daf74550d
schema:url	https://doi.org/10.1016/j.ymeth.2012.06.011
resource representing a document's title	Computational analysis of interactomes: Current and future perspectives for bioinformatics approaches to model the host–pathogen interaction space
has PubMed Central identifier	PMC7128575
has PubMed identifier	22750305
schema:publication	Methods
resource representing a document's body	covid:a46461d35067bed17057cda849bf940daf74550d#body_text
is schema:about of	named entity 'protein-protein interaction networks' named entity 'bioinformatics' named entity 'application' named entity 'consists' named entity 'interacting' named entity 'cost' named entity 'host' named entity 'bioinformatics' named entity 'Current' named entity 'PATHOGEN' named entity 'NEED' named entity 'INTERACTING' named entity 'CONSTRUCT' named entity 'IMPACT' named entity 'TO INVESTIGATE' named entity 'EXPERIMENTAL' named entity 'APPROACHES' named entity 'BIOINFORMATICS' named entity 'PREDICTION' named entity 'HOST' named entity 'THEIR' named entity 'APPROACHES' named entity 'ACCURATE' named entity 'PROSPECTIVE' named entity 'THESE' named entity 'OBTAIN' named entity 'SECOND' named entity 'PROTEIN-PROTEIN INTERACTION' named entity 'SYSTEMS' named entity 'HOST-PATHOGEN INTERACTIONS' named entity 'ASSOCIATED WITH' named entity 'INFECTION' named entity 'DATA' named entity 'PROTOZOA' named entity 'NECESSARY' named entity 'BIOINFORMATICS' named entity 'PERSPECTIVE' named entity 'DETERMINED' named entity 'CHALLENGE' named entity 'COST' named entity 'AFFECT' named entity 'OVERVIEW' named entity 'SUB-' named entity 'POSSIBLE' named entity 'PATHOGEN PROTEIN' named entity 'PROBLEMS' named entity 'RESEARCH' named entity 'ANALYZED' named entity 'NEAR' named entity 'EUKARYOTIC' named entity 'SPACE' named entity 'COMPUTATIONAL ANALYSIS' named entity 'CURRENT' named entity 'MODEL' named entity 'FUTURE' named entity 'BACTERIA ' named entity 'ANALYSIS' named entity 'NUMBER OF' named entity 'VALUE' named entity 'EFFECTOR PROTEINS' named entity 'COVERED' named entity 'CONSTRUCTION' named entity 'CURRENT' named entity 'SALMONELLA' named entity 'REVIEW' named entity 'HAVE' named entity 'VIRAL PATHOGENS' named entity 'AVAILABLE' named entity 'PREDICT' named entity 'COMPLETE' named entity 'NETWORK' named entity 'EXAMPLE' named entity 'APPLICATION' named entity 'PROTEIN INTERACTION NETWORKS' named entity 'PROTEINS' named entity 'DISCUSS' named entity 'METHODS' named entity 'HOST CELL'

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