About: Role of protein kinase R in double-stranded RNA-induced expression of nitric oxide synthase in human astroglia

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About: Role of protein kinase R in double-stranded RNA-induced expression of nitric oxide synthase in human astroglia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Role of protein kinase R in double-stranded RNA-induced expression of nitric oxide synthase in human astroglia
Creator	Pahan, Kalipada Liu, Xiaojuan Auch, Corey Jacobs, Bertram Saha, Ramendra Sheikh, Faruk
Source	Elsevier; Medline; PMC
abstract	Environmental factor(s), such as viral infection, has been implicated as one of the triggering events leading to neuroinflammation in multiple sclerosis. This study underlines the importance of double-stranded RNA (dsRNA), the active component of a viral infection, in inducing the expression of inducible nitric oxide synthase (iNOS) in human astroglia. DsRNA in the form of synthetic polyinosinic-polycytidylic acid (poly IC) induced expression of iNOS and iNOS promoter-driven luciferase activity through activation of nuclear factor (NF)-κB and CCAAT/enhancer-binding proteinβ (C/EBPβ). In addition, we show that inhibitors of protein kinase R attenuated iNOS by suppressing the activation of NF-κB but not C/EBPβ. In contrast, knock down of p38 mitogen-activated protein kinase (MAPK) attenuated iNOS by suppressing the activation of C/EBPβ but not NF-κB. This study delineates a novel role of dsRNA in inducing the expression of iNOS through dsRNA-activated protein kinase (PKR)-mediated activation of NF-κB and p38-mediated activation of C/EBPβ in human astroglia that may participate in virus-induced neurological abnormalities.
has issue date	2004-03-22(xsd:dateTime)
bibo:doi	10.1016/s0014-5793(04)00302-3
bibo:pmid	15063753
has license	green-oa
sha1sum (hex)	a43c247693fadc32757acd23898239a9c8a1d3e8
schema:url	https://doi.org/10.1016/s0014-5793%2804%2900302-3
resource representing a document's title	Role of protein kinase R in double-stranded RNA-induced expression of nitric oxide synthase in human astroglia
has PubMed Central identifier	PMC1986658
has PubMed identifier	15063753
schema:publication	FEBS Letters
resource representing a document's body	covid:a43c247693fadc32757acd23898239a9c8a1d3e8#body_text
is schema:about of	named entity 'PKR' named entity 'inducing' named entity 'p38' named entity 'Societies' named entity 'nitric oxide synthase' named entity 'protein kinase R' named entity 'INDUCING' named entity 'P38 MITOGEN-ACTIVATED PROTEIN KINASE' named entity 'NUCLEAR' named entity 'COMPONENT' named entity 'abnormalities' named entity 'attenuated' named entity 'poly' named entity 'European' named entity 'iNOS' named entity 'protein kinase' named entity 'astroglia' named entity 'human' named entity 'double-stranded RNA' named entity 'virus' named entity 'mitogen-activated protein kinase' named entity 'Environmental factor' named entity 'iNOS' named entity 'induced expression' named entity 'neurological' named entity 'p38' named entity 'dsRNA' named entity 'protein kinase' named entity 'inducible nitric oxide synthase' named entity 'viral infection' named entity 'iNOS' named entity 'University of California at Los Angeles' named entity 'Nitric oxide' named entity 'molecule' named entity 'demyelination' named entity 'astroglial cells' named entity 'CSF' named entity 'viral infections' named entity '0.01' named entity 'antibodies' named entity 'Nitric oxide' named entity 'DNA-binding activity' named entity 'Nuclear proteins' named entity 'dsRNA' named entity 'kinase' named entity 'RNA' named entity 'dsRNA' named entity 'Nitric oxide' named entity 'iNOS' named entity 'Santa Cruz Biotechnology' named entity 'broad-spectrum' named entity 'p38' named entity 'p38' named entity 'iNOS' named entity 'LPS' named entity 'Nitric oxide' named entity 'iNOS' named entity 'induced expression' named entity 'pathogenesis' named entity 'Griess reagent' named entity 'cDNA' named entity 'vector' named entity 'RNA' named entity 'astroglia' named entity 'polyclonal antibodies' named entity 'Santa Cruz Biotechnology' named entity 'dsRNA' named entity 'DNA-binding activity' named entity 'autoimmune' named entity 'iNOS' named entity 'iNOS' named entity 'iNOS' named entity 'C/EBP' named entity 'eukaryotic cells' named entity 'DNA-binding' named entity 'neural cell'

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