About: Baseline pulmonary levels of CD8+ T cells and NK cells inversely correlate with expression of the SARS-CoV-2 entry receptor ACE2

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About: Baseline pulmonary levels of CD8+ T cells and NK cells inversely correlate with expression of the SARS-CoV-2 entry receptor ACE2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Baseline pulmonary levels of CD8+ T cells and NK cells inversely correlate with expression of the SARS-CoV-2 entry receptor ACE2
Creator	Duijf, Pascal
Source	BioRxiv; Medline; PMC
abstract	Coronavirus disease 19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and currently has detrimental human health, community and economic impacts around the world. In SARS-CoV-2-infected lung, induction of immune cell-recruiting cytokines is initially poor. When induction does occur, this may in fact exacerbate infection. These observations suggest that baseline levels of leukocytes, already residing in the lung prior to infection, may be important for orchestrating an effective early immune response. Hence, we performed “in silico flow cytometry” on 1,927 human lung tissues to deconvolute the levels of seven leukocyte types involved in triggering an acute anti-viral cellular immune response. Baseline levels of CD8+ T cells, resting natural killer (NK) cells and activated NK cells are significantly lower in lung tissues with high expression of the SARS-CoV-2 host cell entry receptor ACE2. We observe this in univariate analyses, in multivariate analyses that include sex, age, race, body mass index and smoking history, and in two independent datasets. Elevated ACE2 expression increases sensitivity to coronavirus infection. Thus, our results suggest that a subgroup of individuals may be exceedingly susceptible to COVID-19 due to concomitant high preexisting ACE2 expression and low baseline cytotoxic lymphocyte levels in the lung.
has issue date	2020-05-05(xsd:dateTime)
bibo:doi	10.1101/2020.05.04.075291
bibo:pmid	32511391
has license	cc-by-nc-nd
sha1sum (hex)	a35a19b9f7edd98e43cd784f0d46737f97983975
schema:url	https://doi.org/10.1101/2020.05.04.075291
resource representing a document's title	Baseline pulmonary levels of CD8+ T cells and NK cells inversely correlate with expression of the SARS-CoV-2 entry receptor ACE2
has PubMed Central identifier	PMC7263520
has PubMed identifier	32511391
schema:publication	bioRxiv
resource representing a document's body	covid:a35a19b9f7edd98e43cd784f0d46737f97983975#body_text
is schema:about of	named entity 'HUMAN HEALTH' named entity 'lung' named entity 'infected' named entity 'lung' named entity 'cytokines' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'CD8+ T cells' named entity 'ACE2' named entity 'phenotype' named entity 'Cytokine storm' named entity 'Austria' named entity 'human lung' named entity 'SARS-CoV-2' named entity 'M1 macrophages' named entity 'bioRxiv' named entity 'SARS-CoV2' named entity 'infection' named entity 'virions' named entity 'protein' named entity 'CC-BY-NC-ND 4.0' named entity 'ACE2' named entity 'immune cell' named entity 'epithelial cells' named entity 'gene expression' named entity 'epithelial cells' named entity 'COVID-19' named entity 'COVID' named entity 'viral infection' named entity 'innate immune response' named entity 'infection' named entity 'cell entry' named entity 'SARS-CoV' named entity 'CD8+ T cells' named entity 'COVID-19' named entity 'infection' named entity 'lung tissue' named entity 'NK cells' named entity 'viral particles' named entity 'single-stranded RNA' named entity 'cytokines' named entity 'upregulate' named entity 'multivariate analyses' named entity 'COVID' named entity 'human lung' named entity 'cytokines' named entity 'cDNA' named entity 'bioRxiv' named entity 'Gene expression' named entity 'CD4+ T cells' named entity 'viral infections' named entity 'gene expression' named entity 'NK cells' named entity 'Groningen University' named entity 'ACE2' named entity 'pathogen-associated molecular patterns' named entity 'SARS-CoV-2' named entity '19, 20' named entity 'SARS-CoV-2' named entity 'lung tissue' named entity 'pathogenesis' named entity 'cytotoxic lymphocyte' named entity 'SARS-CoV-2' named entity 'M1 macrophages' named entity 'SARS-CoV-2' named entity 'bioRxiv' named entity 'induced-self' named entity 'leukocyte' named entity 'epidemic' named entity 'leukocyte' named entity 'tissue samples' named entity 'M1 macrophages' named entity 'CD8+ T cells' named entity 'statistically significant' named entity 'Pearson correlation' named entity 'dendritic cells' named entity 'M1 macrophages' named entity 'R Project' named entity 'median absolute deviation' named entity 'chemokines' named entity 'human lung' named entity '2, 3'

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