About: Prediction and In Silico Identification of Novel B-Cells and T-Cells Epitopes in the S1-Spike Glycoprotein of M41 and CR88 (793/B) Infectious Bronchitis Virus Serotypes for Application in Peptide Vaccines

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Prediction and In Silico Identification of Novel B-Cells and T-Cells Epitopes in the S1-Spike Glycoprotein of M41 and CR88 (793/B) Infectious Bronchitis Virus Serotypes for Application in Peptide Vaccines Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Prediction and In Silico Identification of Novel B-Cells and T-Cells Epitopes in the S1-Spike Glycoprotein of M41 and CR88 (793/B) Infectious Bronchitis Virus Serotypes for Application in Peptide Vaccines
Creator	Bande, Faruku Kadkhodaei, Saeid Arshad, Siti Bejo, Mohd Rahman Omar, Abdul
Source	Medline; PMC
abstract	Bioinformatic analysis was used to predict antigenic B-cell and T-cell epitopes within the S1 glycoprotein of M41 and CR88 IBV strains. A conserved linear B-cell epitope peptide, YTSNETTDVTS(175–185), was identified in M41 IBV strains while three such epitopes types namely, VSNASPNSGGVD(279–290), HPKCNFRPENI(328–338), and NETNNAGSVSDCTAGT(54–69), were predicted in CR88 IBV strains. Analysis of MHCI binding peptides in M41 IBV strains revealed the presence of 15 antigenic peptides out of which 12 were highly conserved in 96–100% of the total M41 strains analysed. Interestingly three of these peptides, GGPITYKVM(208), WFNSLSVSI(356), and YLADAGLAI(472), relatively had high antigenicity index (>1.0). On the other hand, 11 MHCI binding epitope peptides were identified in CR88 IBV strains. Of these, five peptides were found to be highly conserved with a range between 90% and 97%. However, WFNSLSVSL(358), SYNISAASV(88), and YNISAASVA(89) peptides comparably showed high antigenicity scores (>1.0). Combination of antigenic B-cells and T-cells peptides that are conserved across many strains as approach to evoke humoral and CTL immune response will potentially lead to a broad-based vaccine that could reduce the challenges in using live attenuated vaccine technology in the control of IBV infection in poultry.
has issue date	2016-09-07(xsd:dateTime)
bibo:doi	10.1155/2016/5484972
bibo:pmid	27667997
has license	cc-by
sha1sum (hex)	a2f961fd82a92373256efd31318904eaa6cf6c64
schema:url	https://doi.org/10.1155/2016/5484972
resource representing a document's title	Prediction and In Silico Identification of Novel B-Cells and T-Cells Epitopes in the S1-Spike Glycoprotein of M41 and CR88 (793/B) Infectious Bronchitis Virus Serotypes for Application in Peptide Vaccines
has PubMed Central identifier	PMC5030393
has PubMed identifier	27667997
schema:publication	Adv Bioinformatics
resource representing a document's body	covid:a2f961fd82a92373256efd31318904eaa6cf6c64#body_text
is schema:about of	named entity 'B-CELLS' named entity 'antigenicity' named entity 'presence' named entity 'high' named entity 'attenuated vaccine' named entity 'Spike' named entity 'Novel' named entity 'Prediction' named entity 'Identification' named entity 'Application' named entity 'EPITOPES' named entity 'IDENTIFICATION' named entity 'NOVEL' named entity 'TOTAL' named entity 'REDUCE' named entity 'EPITOPE PEPTIDE' named entity 'PEPTIDES' named entity 'T-CELL' named entity 'COMBINATION' named entity 'TECHNOLOGY' named entity 'IMMUNE RESPONSE' named entity 'HAND' named entity 'RANGE' named entity '185' named entity 'TYPES' named entity '328' named entity 'VACCINE' named entity '90%' named entity 'CONTROL' named entity 'IBV' named entity '290' named entity 'PREDICTED' named entity 'M41' named entity 'HIGHLY' named entity 'REVEALED' named entity 'PRESENCE OF' named entity 'B-CELL' named entity 'LEAD' named entity 'HIGH' named entity '100%' named entity 'POULTRY' named entity 'EPITOPES' named entity 'INFECTION' named entity '208' named entity 'BINDING' named entity 'LINEAR' named entity 'PREDICT' named entity 'B-CELL EPITOPE' named entity 'SEROTYPES' named entity '3E1' named entity 'IN SILICO' named entity '28793' named entity 'PREDICTION' named entity 'APPLICATION' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'T-CELLS' named entity '2FB' named entity 'INDEX' named entity 'THESE' named entity 'GLYCOPROTEIN' named entity '356' named entity 'EPITOPE' named entity 'STRAINS' named entity 'APPROACH' named entity 'T-CELLS' named entity 'USING' named entity 'USED' named entity 'ANTIGENICITY' named entity 'ANALYSIS' named entity 'BIOINFORMATIC' named entity 'CHALLENGES' named entity 'CR88' named entity 'SCORES' named entity 'IDENTIFIED' named entity 'PEPTIDE VACCINES' named entity 'M41' named entity 'CR88'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software