About: Beclin1 Binds to Enterovirus 71 3D Protein to Promote the Virus Replication

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About: Beclin1 Binds to Enterovirus 71 3D Protein to Promote the Virus Replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Beclin1 Binds to Enterovirus 71 3D Protein to Promote the Virus Replication
Creator	Wu, Jianguo Luo, Zhen Wu, Kailang Yang, Hua Xiang, Qi Huang, Siyu Qin, Mengying Yang, Ge
Source	Medline; PMC
abstract	Enterovirus 71 (EV71) is the main pathogen causing hand-foot-mouth disease (HFMD) in infants and children, which can also lead to severe neurological diseases and even death. Therefore, understanding the replication mechanism of EV71 is of great significance for the prevention and control of EV71-induced diseases. Beclin1 (BECN1, a mammalian homologue of ATG6 in yeast) is an important core protein for the initiation and the normal process of autophagy in cells. In addition to its involvement in autophagy, Beclin1 has also been reported to play an important role in cancer and innate immune signaling pathways. However, the role of Beclin1 in EV71 replication remains elusive. Here, we primarily found that Beclin1 facilitates EV71 replication in human rhabdomyosarcoma (RD) cells and the autophagy was actually induced, but Beclin1 was not significantly affected at either mRNA level or protein level during early EV71 infection. Further studies discovered that Beclin1 could interacts with EV71 non-structural protein 3D mainly through its evolutionary conserved domain (ECD) and coiled-coiled domain (CCD), thus promoting the replication of EV71 in human rhabdomyosarcoma (RD) cells and human astroglioma (U251) cells. Collectively, we reveal a novel regulatory mechanism associated with Beclin1 to promote EV71 replication, thus providing a potential therapeutic target for the prevention and control of EV71-associated diseases.
has issue date	2020-07-14(xsd:dateTime)
bibo:doi	10.3390/v12070756
bibo:pmid	32674313
has license	cc-by
sha1sum (hex)	a15e84048178ca2998e0c20557e6aa4cf3fae773
schema:url	https://doi.org/10.3390/v12070756
resource representing a document's title	Beclin1 Binds to Enterovirus 71 3D Protein to Promote the Virus Replication
has PubMed Central identifier	PMC7411969
has PubMed identifier	32674313
schema:publication	Viruses
resource representing a document's body	covid:a15e84048178ca2998e0c20557e6aa4cf3fae773#body_text
is schema:about of	named entity 'induced' named entity 'induced' named entity 'autophagy' named entity 'yeast' named entity 'LEVEL' named entity 'AFFECTED' named entity 'ASTROGLIOMA' named entity 'NON-' named entity 'STUDIES' named entity 'MRNA' named entity 'human' named entity 'mRNA' named entity 'process' named entity 'Further' named entity 'innate immune' named entity 'rhabdomyosarcoma' named entity 'Therefore' named entity 'neurological diseases' named entity 'core protein' named entity 'autophagy' named entity 'EV71' named entity 'Beclin1' named entity 'U251' named entity 'Beclin1' named entity 'ATG6' named entity 'yeast' named entity 'autophagy' named entity 'vector' named entity 'dose-dependent manner' named entity 'transfected' named entity 'EV71' named entity 'RdRp' named entity '5′UTR' named entity 'China' named entity 'EV71' named entity 'EV71' named entity 'tamoxifen' named entity 'EV71' named entity 'Beclin1' named entity 'infection' named entity 'Beclin1' named entity 'viral titer' named entity 'EV71' named entity 'infection' named entity 'EV71' named entity 'Beclin1' named entity 'Beclin1' named entity 'Beclin1' named entity 'autolysosome' named entity 'VP1' named entity 'nonstructural protein' named entity 'EV71' named entity 'autophagy' named entity 'Beclin1' named entity 'GFP' named entity 'EV71' named entity 'protein' named entity 'Hepes' named entity 'Beclin1' named entity 'EV71' named entity 'HEK293T' named entity 'pandemic strains' named entity 'IFN' named entity 'autophagy' named entity 'vaccines' named entity 'Beclin1' named entity 'RNA' named entity 'Beclin1' named entity 'Coronavirus' named entity 'infection' named entity 'Beclin1' named entity 'Bio-Rad' named entity 'infection' named entity 'Protease Inhibitor'

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