About: Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: A multicenter cohort study

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About: Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: A multicenter cohort study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: A multicenter cohort study
Creator	Zheng, Ming-Hua Li, Xiaodan Zhang, Lin Li, Xinyu Xu, Dan Mei, Mei Liu, Tao Zhang, Guo Yang, Hua Pan, Hongqiu Liu, Huiling Liu, Yanna Qi, Xiaolong Liu, Chuan Zhang, Hongguang Wang, Jitao Gu, Ye Li, Xun He, Qing Jiang, Zicheng Li, Jinlin Shao, Chuxiao Zou, Shengqiang Chen, Zhenhuai Fallowfield, Jonathan Huang, Yifei Kang, Ning Kawada, Norifumi Li, Fujian Li, Xiaoguo Liu, Dengxiang Luo, Yan Rockey, Don Shi, Jindong Takehara, Tetsuo Wang, Jianwen Wang, Fengmei Wang, Zhengyan Xiong, Bin Xiang, Huihua
Source	MedRxiv
abstract	Background: Patients with pre-existing cirrhosis are considered at increased risk of severe coronavirus disease 2019 (COVID-19) but the clinical course in these patients has not yet been reported. This study aimed to provide a detailed report of the clinical characteristics and outcomes among COVID-19 patients with pre-existing cirrhosis. Methods: In this retrospective, multicenter cohort study, we consecutively included all adult inpatients with laboratory-confirmed COVID-19 and pre-existing cirrhosis that had been discharged or had died by 24 March 2020 from 16 designated hospitals in China. Demographic, clinical, laboratory and radiographic findings on admission, treatment, complications during hospitalization and clinical outcomes were collected and compared between survivors and non-survivors. Findings: Twenty-one patients were included in this study, of whom 16 were cured and 5 died in hospital. Seventeen patients had compensated cirrhosis and hepatitis B virus infection was the most common etiology. Lymphocyte and platelet counts were lower, and direct bilirubin levels were higher in patients who died than those who survived (p= 0.040, 0.032, and 0.006, respectively). Acute respiratory distress syndrome and secondary infection were both the most frequently observed complications. Only one patient developed acute on chronic liver failure. Of the 5 non-survivors, all patients developed acute respiratory distress syndrome and 2 patients progressed to multiple organ dysfunction syndrome. Interpretation: Lower lymphocyte and platelet counts, and higher direct bilirubin level might represent poor prognostic indicators in SARS-CoV-2-infected patients with pre-existing cirrhosis.
has issue date	2020-04-28(xsd:dateTime)
bibo:doi	10.1101/2020.04.24.20072611
has license	medrxiv
sha1sum (hex)	a08d4b749b4d5b73acfa15344195a097a9699c96
schema:url	https://doi.org/10.1101/2020.04.24.20072611
resource representing a document's title	Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: A multicenter cohort study
resource representing a document's body	covid:a08d4b749b4d5b73acfa15344195a097a9699c96#body_text
is schema:about of	named entity 'COVID-19' named entity 'risk factors' named entity 'multicenter' named entity 'cirrhosis' named entity 'pre-existing' named entity 'direct bilirubin' named entity 'Leukopenia' named entity 'MELD' named entity 'medRxiv' named entity 'lopinavir' named entity 'chronic liver disease' named entity 'Cirrhosis' named entity 'co-infection' named entity 'direct bilirubin' named entity 'clinical characteristics' named entity 'secondary infection' named entity 'monotherapy' named entity 'medRxiv' named entity 'fever' named entity 'ground-glass opacities' named entity 'peer review' named entity 'lymphopenia' named entity 'innate immune responses' named entity 'monotherapy' named entity 'cirrhosis' named entity 'IgM' named entity 'pulmonary disease' named entity 'peer review' named entity 'medRxiv' named entity 'liver' named entity 'cirrhosis' named entity 'risk factors' named entity 'severe acute respiratory syndrome coronavirus' named entity 'COVID' named entity 'malignancy' named entity 'medRxiv' named entity 'SARS-CoV-2' named entity 'lymphocyte' named entity 'cirrhosis' named entity 'serum albumin' named entity 'medical institutions' named entity 'cardiovascular disease' named entity 'cough' named entity 'COVID' named entity 'Child-Pugh' named entity 'Lymphocyte'

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