About: Multimodality cardiac evaluation in children and young adults with multisystem inflammation associated with COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multimodality cardiac evaluation in children and young adults with multisystem inflammation associated with COVID-19
Creator	Adhvaryu, Kaitav Cleary, Aoife Heard, Hannah Kabir, Saleha Mathur, Sujeev Miller, Owen Pascall, Emma Peacock, Kelly Pushparajah, Kuberan Savis, Alex Simpson, John Stewart, Kirsty Theocharis, Paraskevi Uy, Mirasol Wong, James
Source	Medline; PMC
abstract	AIMS: Following the peak of the UK COVID-19 epidemic, a new multisystem inflammatory condition with significant cardiovascular effects emerged in young people. We utilized multimodality imaging to provide a detailed sequential description of the cardiac involvement. METHODS AND RESULTS: Twenty consecutive patients (mean age 10.6 ± 3.8 years) presenting to our institution underwent serial echocardiographic evaluation on admission (median day 5 of illness), the day coinciding with worst cardiac function (median day 7), and the day of discharge (median day 15). We performed cardiac computed tomography (CT) to assess coronary anatomy (median day 15) and cardiac magnetic resonance imaging (CMR) to assess dysfunction (median day 20). On admission, almost all patients displayed abnormal strain and tissue Doppler indices. Three-dimensional (3D) echocardiographic ejection fraction (EF) was <55% in half of the patients. Valvular regurgitation (75%) and small pericardial effusions (10%) were detected. Serial echocardiography demonstrated that the mean 3D EF deteriorated (54.7 ± 8.3% vs. 46.4 ± 8.6%, P = 0.017) before improving at discharge (P = 0.008). Left main coronary artery (LMCA) dimensions were significantly larger at discharge than at admission (Z score –0.11 ± 0.87 vs. 0.78 ± 1.23, P = 0.007). CT showed uniform coronary artery dilatation commonly affecting the LMCA (9/12). CMR detected abnormal strain in all patients with global dysfunction (EF <55%) in 35%, myocardial oedema in 50%, and subendocardial infarct in 5% (1/20) patients. CONCLUSIONS: Pancarditis with cardiac dysfunction is common and associated with myocardial oedema. Patients require close monitoring due to coronary artery dilatation and the risk of thrombotic myocardial infarction.
has issue date	2020-08-07(xsd:dateTime)
bibo:doi	10.1093/ehjci/jeaa212
bibo:pmid	32766671
has license	no-cc
schema:url	https://doi.org/10.1093/ehjci/jeaa212
resource representing a document's title	Multimodality cardiac evaluation in children and young adults with multisystem inflammation associated with COVID-19
has PubMed Central identifier	PMC7454452
has PubMed identifier	32766671
schema:publication	Eur Heart J Cardiovasc Imaging
resource representing a document's body	covid:PMC7454452#body_text
is schema:about of	named entity 'inflammation' named entity 'cardiac' named entity 'CMR' named entity 'SARS-CoV-2 pandemic' named entity 'LCx' named entity 'Statistical significance' named entity 'Germany' named entity 'normal distribution' named entity 'NT-proBNP' named entity '0.80' named entity 'LCx' named entity 'EPIQ' named entity 'oedema' named entity 'left ventricular' named entity 'end-systolic volume' named entity 'KDSS' named entity 'serum' named entity 'BSA' named entity 'echocardiographic' named entity 'LMCA' named entity 'echocardiographic' named entity 'necrosis' named entity 'SARS-CoV-2' named entity 'LCx' named entity 'ECG' named entity 'systolic' named entity 'oedema' named entity 'echocardiographic' named entity 'BSA' named entity 'Statistical analysis' named entity 'mitral annulus' named entity 'PSIR' named entity 'aneurysms' named entity 'diagnostic criteria' named entity 'left coronary artery' named entity 'T2-weighted' named entity 'body surface area' named entity 'Intraluminal' named entity 'bSSFP' named entity 'Cardiac involvement' named entity 'LMCA' named entity 'IgM' named entity 'echocardiographic' named entity 'macrophage activation syndrome' named entity 'echocardiography' named entity 'echocardiographic' named entity 'myocardial infarction' named entity 'endocardium' named entity 'Philips Medical Systems' named entity 'World Health Organization' named entity 'Cardiac CT' named entity '3D echocardiography' named entity 'T2-weighted' named entity 'M-mode' named entity 'cardiac magnetic resonance imaging' named entity 'ESV' named entity 'diastolic' named entity 'oropharyngeal' named entity 'Field of view' named entity 'Canada' named entity 'coronary artery' named entity 'coronary artery' named entity 'ejection fraction' named entity 'Siemens Healthcare' named entity 'echocardiographic' named entity 'general anaesthetic' named entity 'ethical approval' named entity 'computed tomography'

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