About: Alteration of immunological parameters in Infectious Bronchitis vaccinated-specific pathogen free broilers after the use of different Infectious Bursal Disease vaccines

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About: Alteration of immunological parameters in Infectious Bronchitis vaccinated-specific pathogen free broilers after the use of different Infectious Bursal Disease vaccines Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Alteration of immunological parameters in Infectious Bronchitis vaccinated-specific pathogen free broilers after the use of different Infectious Bursal Disease vaccines
Creator	Catelli, Elena Lupini, Caterina Boldini, Sara Mescolini, Giulia Monica, Forni Quaglia, Giulia Russo, Elisa Salaroli, Roberta
Source	Elsevier; PMC
abstract	The vaccines currently available to control infectious bursal disease (IBD) include live-attenuated and inactivated vaccines, immune-complex vaccines and vaccines consisting of viral constructs of herpesvirus of turkeys (HVT) genetically engineered in order to express VP2 surface protein. In order to evaluate the impact of vaccines on the chicken immune system, two animal trials were performed in Specific Pathogen Free (SPF) broiler chickens. In trial 1 birds were either vaccinated at one day-old with a dual rHVT construct vaccine, expressing VP2 protein of IBDV and F protein of Newcastle disease virus, or an immune-complex IBDV vaccine or birds were not vaccinated. At 14, 28 and 35 days, the bursas of Fabricius were collected for bursa:body weight (B:BW) ratio calculation. In trial 2, birds were vaccinated at one-day old according to the same protocol as trial 1, but at day 14 all groups also received a live infectious bronchitis (IB) vaccine. At 0, 7, 14, 21 and 28-days post IB vaccination, birds were tested by ELISA for IB serology, and, soon after the last blood sampling, they were euthanized for collection of Harderian glands, trachea and spleen and testing by flow cytometry for characterization of mononuclear cells. The immune-complex vaccine groups showed significantly lower B:BW ratio, lower IBV antibody titers and higher mean percentage of CD8+ T cells in spleen, trachea and Harderian glands when compared to the other experimental groups. The results of the in vivo trials coupled with a depth analysis of the repertoire of parameters involved in the immune response to IBD and IB vaccinations show as one vaccine may influence the immune response of other vaccines included in the vaccination program.
has issue date	2020-06-26(xsd:dateTime)
bibo:doi	10.1016/j.psj.2020.05.054
has license	no-cc
schema:url	https://doi.org/10.1016/j.psj.2020.05.054
resource representing a document's title	Alteration of immunological parameters in Infectious Bronchitis vaccinated-specific pathogen free broilers after the use of different Infectious Bursal Disease vaccines
has PubMed Central identifier	PMC7318956
schema:publication	Poult Sci
resource representing a document's body	covid:PMC7318956#body_text
is schema:about of	named entity 'pathogen' named entity 'Bronchitis' named entity 'specific pathogen free' named entity 'immunological' named entity 'trachea' named entity 'antibodies' named entity 'staining' named entity 'Bergisch Gladbach' named entity 'biosafety' named entity 'dead cells' named entity 'mononuclear cells' named entity 'CD8+ T cells' named entity 'IBD' named entity 'leukocyte' named entity 'IBDV' named entity 'CD8+' named entity 'specific pathogen free' named entity 'tracheas' named entity 'live-attenuated' named entity 'MSD Animal Health' named entity 'MSD Animal Health' named entity 'tonsils' named entity 'IBV' named entity 'broiler chickens' named entity 'IBDV' named entity 'IBDV' named entity 'Fabricius' named entity 'interphase' named entity 'IBDV' named entity 'CD8+ T cells' named entity 'IBDV' named entity 'IBDV' named entity 'CD45' named entity 'antibodies' named entity 'IBV' named entity 'IBDV' named entity 'mononuclear cells' named entity 'infection' named entity 'serotype' named entity 'subcutaneous' named entity 'IBDV' named entity 'Mononuclear cells' named entity 'SPF' named entity 'poultry production' named entity 'Miltenyi Biotec' named entity 'IBDV' named entity 'cytotoxic T lymphocytes' named entity 'vaccination' named entity 'Harderian' named entity 'IBDV' named entity 'IBDV' named entity 'IBDV' named entity 'IBV' named entity 'post-mortem examination' named entity 'trachea' named entity 'Avibirnavirus' named entity 'spleens' named entity 'IBDV' named entity 'Harderian' named entity 'avian coronavirus' named entity 'vaccination' named entity 'lymphocyte' named entity 'antibodies' named entity 'poultry farms' named entity 'Harderian' named entity 'control group' named entity 'Jackwood' named entity 'serotypes' named entity 'IBD' named entity 'IBV' named entity 'protein' named entity 'SPF' named entity 'IBV' named entity 'inoculated' named entity 'IBD' named entity 'flow cytometry' named entity 'protein'

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