About: What makes non-cirrhotic portal hypertension a common disease in India? Analysis for environmental factors

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	What makes non-cirrhotic portal hypertension a common disease in India? Analysis for environmental factors
Creator	Balasubramanian, K.A. Eapen, C.E. Elias, Elwyn Goel, Ashish Ramakrishna, Banumathi Sajith, K.G. Zachariah, Uday Burad, Deepak Keshava, Shyamkumar Kodiatte, Thomas
source	Medline; PMC
abstract	In India, an unexplained enteropathy is present in a majority of non-cirrhotic intrahepatic portal hypertension (NCIPH) patients. Small intestinal bacterial contamination and tropical enteropathy could trigger inflammatory stimuli and activate the endothelium in the portal venous system. Groundwater contaminated with arsenic is an environmental factor of epidemic proportions in large areas of India which has similar consequences. Von Willebrand factor (a sticky protein) expressed by activated endothelium may promote formation of platelet microthrombi and occlusion of intrahepatic portal vein branches leading to NCIPH. Environmental factors linked to suboptimal hygiene and sanitation, which enter through the gastrointestinal (GI) tract, predispose to platelet plugging onto activated endothelium in portal microcirculation. Thus, NCIPH, an example of poverty linked thrombophilia, is a disease mainly affecting the lower socio-economic strata of Indian population. Public health measures to improve sanitation, provide clean drinking water and eliminate arsenic contamination of drinking water are urgently needed. Till such time as these environmental factors are addressed, NCIPH is likely to remain 'an Indian disease'.
has issue date	2019-04-01(xsd:dateTime)
bibo:doi	10.4103/ijmr.ijmr_1405_17
bibo:pmid	31411170
has license	cc-by-nc-sa
schema:url	https://doi.org/10.4103/ijmr.ijmr_1405_17
resource representing a document's title	What makes non-cirrhotic portal hypertension a common disease in India? Analysis for environmental factors
has PubMed Central identifier	PMC6676844
has PubMed identifier	31411170
schema:publication	Indian J Med Res
resource representing a document's body	covid:PMC6676844#body_text
is schema:about of	named entity 'India' named entity 'Ayurvedic medicines' named entity 'genetic factors' named entity 'chronic hepatitis' named entity 'endothelium' named entity 'malabsorption' named entity 'venous pressure' named entity 'liver' named entity 'ADAMTS13' named entity 'portal hypertension' named entity 'arsenic' named entity 'cirrhotic' named entity 'tropical sprue' named entity 'Tibet' named entity 'portal hypertension' named entity 'cirrhosis' named entity 'Swatch Bharat' named entity 'B12 deficiency' named entity 'lungs' named entity 'complement' named entity 'psoriasis' named entity 'socio-economic' named entity 'liver' named entity 'tropical sprue' named entity 'Epidemics' named entity 'Howrah' named entity 'arsenicosis' named entity 'Multifactorial' named entity 'portal hypertension' named entity 'pathogenesis' named entity 'histology' named entity 'urinary bladder' named entity 'South 24 Parganas' named entity 'cirrhosis' named entity 'thrombocytopenia' named entity 'endemic' named entity 'ground water' named entity 'arsenic' named entity 'cirrhosis' named entity 'herbal products' named entity 'Fowler's solution' named entity 'thrombotic microangiopathy' named entity 'platelets' named entity 'portal hypertension' named entity 'pathogenesis' named entity 'stellate cells' named entity 'arsenic' named entity 'thrombospondin' named entity 'Celiac disease' named entity 'anti-cardiolipin' named entity 'portal hypertension' named entity 'hepatic venous pressure gradient' named entity 'kidney' named entity 'environmental factors' named entity 'protein' named entity 'arsenic' named entity 'serum vitamin B12' named entity 'prospective study' named entity 'Clean India' named entity 'CUB domain' named entity 'portal vein' named entity 'hepatic fibrosis' named entity 'cryptogenic' named entity 'Kolkata Municipal Corporation' named entity 'hyperpigmentation' named entity 'sanitation' named entity 'prospective study' named entity 'ADAMTS13' named entity 'hyperactive' named entity 'liver' named entity 'arsenic' named entity 'Escherichia coli' named entity 'pro-inflammatory cytokines'

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