About: Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe

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About: Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe
Creator	Leung, Chung-Hang Ma, Dik-Lung Lin, Sheng Wang, Yi-Tao He, Bingyong He, Hong-Zhang Leung, Ka-Ho Zhong, Hai-Jing
Source	Medline; PMC
abstract	A series of luminescent Ir(iii) complexes were synthesised and evaluated for their ability to act as luminescent G-quadruplex-selective probes. The Ir(iii) complex 9, [Ir(phq)(2)(phen)]PF(6) (where phq = 2-phenylquinoline; phen = 1,10-phenanthroline), exhibited high luminescence in the presence of G-quadruplex DNA compared to dsDNA and ssDNA, and was employed to construct a label-free G-quadruplex-based assay for hepatitis C virus NS3 helicase activity in aqueous solution. Moreover, the application of the assay for screening potential helicase inhibitors was demonstrated. To our knowledge, this is the first G-quadruplex-based assay for helicase activity.
has issue date	2015-04-01(xsd:dateTime)
bibo:doi	10.1039/c4sc03319a
bibo:pmid	28808523
has license	cc-by
schema:url	https://doi.org/10.1039/c4sc03319a
resource representing a document's title	Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe
has PubMed Central identifier	PMC5539802
has PubMed identifier	28808523
schema:publication	Chem Sci
resource representing a document's body	covid:PMC5539802#body_text
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