About: Predisposing factors, pathogenesis and therapeutic intervention of Kawasaki disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Predisposing factors, pathogenesis and therapeutic intervention of Kawasaki disease
Creator	Galeotti, Caroline Bayry, Jagadeesh Cimaz, Rolando Kaveri, Srini Koné -Paut, Isabelle
Source	Elsevier; Medline; PMC
abstract	Kawasaki disease (KD) is an acute febrile childhood inflammatory disease, associated with coronary artery abnormalities. The disease is believed to result from an aberrant inflammatory response to an infectious trigger in a genetically predisposed individual. KD is associated with an endothelial cell injury as a consequence of T cell activation and cytotoxic effects of various proinflammatory cytokines. Intravenous immunoglobulin (IVIG) infusion and aspirin are the standard treatment of acute KD. However, 10–20% of patients show resistance to IVIG therapy and present higher risk of coronary vasculitis. The relative roles of second IVIG infusion, corticosteroids, calcineurin inhibitors, interleukin-1 antagonists and anti-tumor necrosis factor agents remain uncertain. In this review, we highlight the predisposing factors, pathogenesis and therapeutic intervention of KD, particularly new therapeutics for IVIG-resistant patients.
has issue date	2016-08-06(xsd:dateTime)
bibo:doi	10.1016/j.drudis.2016.08.004
bibo:pmid	27506874
has license	no-cc
sha1sum (hex)	9f95a439476a71a0a9b14f5933b4f3881cd21d0d
schema:url	https://doi.org/10.1016/j.drudis.2016.08.004
resource representing a document's title	Predisposing factors, pathogenesis and therapeutic intervention of Kawasaki disease
has PubMed Central identifier	PMC7185772
has PubMed identifier	27506874
schema:publication	Drug Discov Today
resource representing a document's body	covid:9f95a439476a71a0a9b14f5933b4f3881cd21d0d#body_text
is schema:about of	named entity 'vasculitis' named entity 'proinflammatory cytokines' named entity 'IVIG' named entity 'therapeutic intervention' named entity 'PREDISPOSING FACTORS' named entity 'UNCERTAIN' named entity 'VARIOUS' named entity 'FEBRILE' named entity 'SECOND' named entity 'PREDISPOSING FACTORS' named entity 'RESULT' named entity 'INTRAVENOUS IMMUNOGLOBULIN' named entity 'T CELL ACTIVATION' named entity 'RESISTANCE TO' named entity 'TUMOR NECROSIS FACTOR ' named entity 'CORTICOSTEROIDS' named entity 'HIGHER' named entity 'CALCINEURIN INHIBITORS' named entity 'PATIENTS' named entity 'ANTAGONISTS' named entity 'PATHOGENESIS' named entity 'PRESENT' named entity 'DISEASE' named entity 'RISK OF' named entity 'TRIGGER' named entity 'NEW' named entity 'THERAPEUTICS' named entity 'PROINFLAMMATORY CYTOKINES' named entity 'ASSOCIATED WITH' named entity 'INFUSION' named entity 'RESPONSE TO' named entity 'PREDISPOSED' named entity 'REVIEW' named entity 'CONSEQUENCE OF' named entity 'THERAPEUTIC INTERVENTION' named entity '20%' named entity 'THERAPEUTIC INTERVENTION' named entity 'RELATIVE' named entity 'STANDARD TREATMENT' named entity 'IVIG' named entity 'INFLAMMATORY RESPONSE' named entity 'ANTI-TUMOR NECROSIS FACTOR' named entity 'CELL INJURY' named entity 'INFECTIOUS' named entity 'ENDOTHELIAL CELL' named entity 'INDIVIDUAL' named entity 'ASPIRIN' named entity 'INTERLEUKIN-1 ' named entity 'EFFECTS' named entity 'CYTOTOXIC' named entity 'ACUTE' named entity 'RESISTANT' named entity 'CHILDHOOD' named entity 'KAWASAKI DISEASE' named entity 'CORONARY ARTERY' named entity 'PATHOGENESIS' named entity 'ABERRANT' named entity 'ABNORMALITIES' named entity 'CORONARY VASCULITIS' named entity 'INFLAMMATORY DISEASE' named entity 'KAWASAKI DISEASE' named entity 'ROLES' named entity 'infusion' named entity 'cytotoxic' named entity 'patients' named entity 'relative' named entity 'proinflammatory cytokines' named entity 'inflammatory disease' named entity 'pathogenesis' named entity 'interleukin-1' named entity 'Kawasaki disease' named entity 'arterial wall' named entity 'coronary artery' named entity 'vasculitis' named entity 'retrospective studies' named entity 'ITPKC' named entity 'NLRP3'

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