About: Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology
Creator	Lucchinetti, Claudia Guo, · Boire, Nicholas Constantopoulos, Eleni Kashani, B Kianoush, · Reichard, R
source	Medline; PMC
abstract	We report the neuropathological findings of a patient who died from complications of COVID-19. The decedent was initially hospitalized for surgical management of underlying coronary artery disease. He developed post-operative complications and was evaluated with chest imaging studies. The chest computed tomography (CT) imaging results were indicative of COVID-19 and he was subsequently tested for SARS-CoV-2, which was positive. His condition worsened and he died after more than 2 weeks of hospitalization and aggressive treatment. The autopsy revealed a range of neuropathological lesions, with features resembling both vascular and demyelinating etiologies. Hemorrhagic white matter lesions were present throughout the cerebral hemispheres with surrounding axonal injury and macrophages. The subcortical white matter had scattered clusters of macrophages, a range of associated axonal injury, and a perivascular acute disseminated encephalomyelitis (ADEM)-like appearance. Additional white matter lesions included focal microscopic areas of necrosis with central loss of white matter and marked axonal injury. Rare neocortical organizing microscopic infarcts were also identified. Imaging and clinical reports have demonstrated central nervous system complications in patients’ with COVID-19, but there is a gap in our understanding of the neuropathology. The lesions described in this case provide insight into the potential parainfectious processes affecting COVID-19 patients, which may direct clinical management and ongoing research into the disease. The clinical course of the patient also illustrates that during prolonged hospitalizations neurological complications of COVID may develop, which are particularly difficult to evaluate and appreciate in the critically ill.
has issue date	2020-05-24(xsd:dateTime)
bibo:doi	10.1007/s00401-020-02166-2
bibo:pmid	32449057
has license	cc-by
sha1sum (hex)	9d2501ea33ed4dfa6bd4d594b95843cf4330bd8f
schema:url	https://doi.org/10.1007/s00401-020-02166-2
resource representing a document's title	Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology
has PubMed Central identifier	PMC7245994
has PubMed identifier	32449057
schema:publication	Acta Neuropathol
resource representing a document's body	covid:9d2501ea33ed4dfa6bd4d594b95843cf4330bd8f#body_text
is schema:about of	named entity 'demonstrated' named entity 'patients' named entity 'COVID-19' named entity 'The chest' named entity 'evaluated' named entity 'indicative' named entity 'loss' named entity 'white matter' named entity 'potential' named entity 'pathology' named entity 'EVALUATE' named entity 'MARKED' named entity 'PERIVASCULAR' named entity 'CLINICAL REPORTS' named entity 'WHITE MATTER' named entity 'LIKE' named entity 'RESULTS' named entity 'Imaging' named entity 'ADEM' named entity 'decedent' named entity 'necrosis' named entity 'axonal' named entity 'injury' named entity 'acute disseminated encephalomyelitis' named entity 'imaging' named entity 'white matter' named entity 'condition' named entity 'lesions' named entity 'developed' named entity 'axonal' named entity 'COVID-19' named entity 'range' named entity 'etiologies' named entity 'perivascular' named entity 'axonal injury' named entity 'chest imaging' named entity 'COVID-19' named entity 'white matter' named entity 'autopsy' named entity 'Hemorrhagic' named entity 'acute disseminated encephalomyelitis' named entity 'areas' named entity 'blood vessels' named entity 'infarcts' named entity 'neurons' named entity 'exertional dyspnea' named entity 'airway' named entity 'Creative Commons licence' named entity 'intubation' named entity 'eosinophilic' named entity 'demyelination' named entity 'immunostain' named entity 'ischemic heart disease' named entity 'gross examination' named entity 'pathological processes' named entity 'shock state' named entity 'infarct' named entity 'COVID-19' named entity 'necrosis' named entity 'infarct' named entity 'oligodendrocyte' named entity 'SARS' named entity 'myelin' named entity 'gross examination' named entity 'cerebellum' named entity 'white matter' named entity 'nodules' named entity 'APP' named entity 'ADEM' named entity 'spinal cord' named entity 'axonal injury' named entity 'MERS-CoV' named entity 'coronavirus disease' named entity 'SARS' named entity 'white matter lesions'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software