About: Pulmonary inflammation and cytokine dynamics of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during A(H1N1)pdm09 influenza infection

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About: Pulmonary inflammation and cytokine dynamics of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during A(H1N1)pdm09 influenza infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pulmonary inflammation and cytokine dynamics of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during A(H1N1)pdm09 influenza infection
Creator	Morishima, Tsuneo Hasegawa, Hideki Ainai, Akira Nakajima, Noriko Atsuta, Ryo Fujimoto, Yousuke Hasegawa, Shunji Itoh, Hiroshi Matsushige, Takeshi Nakamura, Tamaki Oga, Atsunori Ohga, Shouichi Shirabe, Komei Toda, Shoichi Wakiguchi, Hiroyuki
Source	PMC
abstract	Asthmatic patients present more rapid progression of respiratory distress after A(H1N1)pdm09 influenza infection than after seasonal infection. Here, we sought to clarify the pathophysiology of early deterioration in asthmatic patients after A(H1N1)pdm09 infection. Cytokine levels and virus titres in bronchoalveolar lavage fluid from mice with and without asthma after A(H1N1)pdm09 or seasonal H1N1 infection were examined. In asthma/A(H1N1)pdm09 mice, IL-6 and TNF-α levels peaked at 3 days post-infection and were higher than those in all other groups. IFN-γ levels in asthma/A(H1N1)pdm09 mice at 3 days post-infection were higher than in all other mice at any time point, whereas at 7 days post-infection, the levels were lowest in asthma/A(H1N1)pdm09 mice. Virus titres in asthma/A(H1N1)pdm09 mice were highest at 3 days post-infection, and decreased by 7 days post-infection, although the levels at this time point were still higher than that in any other group. Histopathological examination showed more inflammatory cell infiltration and lung tissue destruction in the asthma/A(H1N1)pdm09 group than in any other group. The distinct cytokine profiles in A(H1N1)pdm09-infected asthmatic mice indicated excessive inflammation and virus replication within a few days after infection. Thus, bronchial asthma could be a more exacerbating factor for pandemic influenza infection than for seasonal influenza infection.
has issue date	2017-08-22(xsd:dateTime)
bibo:doi	10.1038/s41598-017-08030-w
bibo:pmid	28831046
has license	cc-by
sha1sum (hex)	9be43ef72c2f72b8ea4608d4a744b1ac7b7627fc
schema:url	https://doi.org/10.1038/s41598-017-08030-w
resource representing a document's title	Pulmonary inflammation and cytokine dynamics of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during A(H1N1)pdm09 influenza infection
has PubMed Central identifier	PMC5567326
has PubMed identifier	28831046
schema:publication	Sci Rep
resource representing a document's body	covid:9be43ef72c2f72b8ea4608d4a744b1ac7b7627fc#body_text
is schema:about of	named entity 'progression' named entity 'A(H1N1)' named entity 'RESPIRATORY DISTRESS' named entity 'LOWEST' named entity 'LUNG TISSUE' named entity 'EXAMINED' named entity 'LEVELS' named entity 'EARLY' named entity 'ASTHMATIC' named entity 'IL-6' named entity 'RAPID PROGRESSION' named entity 'INFLUENZA INFECTION' named entity 'A(H1N1)' named entity 'mice' named entity 'A(H1N1)' named entity 'infection' named entity 'lung' named entity 'levels' named entity 'Histopathological' named entity 'seasonal' named entity 'rapid' named entity 'mouse' named entity 'bronchial asthma' named entity 'Pulmonary' named entity 'Virus' named entity 'infection' named entity 'mice' named entity 'mice' named entity 'infection' named entity 'infection' named entity 'H1N1' named entity 'asthma' named entity 'mice' named entity 'bronchoalveolar lavage fluid' named entity 'influenza infection' named entity 'asthma' named entity 'infection' named entity 'infection' named entity 'mice' named entity 'A(H1N1)pdm09' named entity 'infection' named entity 'anti-viral' named entity '0.01' named entity 'A(H1N1)pdm09' named entity 'A(H1N1)pdm09' named entity 'infection' named entity 'asthma' named entity 'Th2' named entity 'A(H1N1)pdm09' named entity 'allergen' named entity 'virus' named entity 'CD8 +' named entity 'infection' named entity 'virus' named entity 'IL-1β' named entity 'infection' named entity 'IL-6' named entity 'IL-2' named entity 'mice' named entity 'lungs' named entity 'mice' named entity 'A(H1N1)pdm09' named entity 'mice' named entity 'Bronchial asthma' named entity 'inflammation' named entity 'infection' named entity 'infection'

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