About: Establishment of a Bluetongue Virus Infection Model in Mice that Are Deficient in the Alpha/Beta Interferon Receptor

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About: Establishment of a Bluetongue Virus Infection Model in Mice that Are Deficient in the Alpha/Beta Interferon Receptor Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Establishment of a Bluetongue Virus Infection Model in Mice that Are Deficient in the Alpha/Beta Interferon Receptor
Creator	Anguita, J Calvo-Pinilla, E Ortego, J Rodríguez-Calvo, T Sevilla, N
Source	Medline; PMC
abstract	Bluetongue (BT) is a noncontagious, insect-transmitted disease of ruminants caused by the bluetongue virus (BTV). A laboratory animal model would greatly facilitate the studies of pathogenesis, immune response and vaccination against BTV. Herein, we show that adult mice deficient in type I IFN receptor (IFNAR((−/−))) are highly susceptible to BTV-4 and BTV-8 infection when the virus is administered intravenously. Disease was characterized by ocular discharges and apathy, starting at 48 hours post-infection and quickly leading to animal death within 60 hours of inoculation. Infectious virus was recovered from the spleen, lung, thymus, and lymph nodes indicating a systemic infection. In addition, a lymphoid depletion in spleen, and severe pneumonia were observed in the infected mice. Furthermore, IFNAR((−/−)) adult mice immunized with a BTV-4 inactivated vaccine showed the induction of neutralizing antibodies against BTV-4 and complete protection against challenge with a lethal dose of this virus. The data indicate that this mouse model may facilitate the study of BTV pathogenesis, and the development of new effective vaccines for BTV.
has issue date	2009-04-09(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0005171
bibo:pmid	19357779
has license	cc-by
sha1sum (hex)	9a9f7135f8ea0664e278c913bc12bb1413b09d4c
schema:url	https://doi.org/10.1371/journal.pone.0005171
resource representing a document's title	Establishment of a Bluetongue Virus Infection Model in Mice that Are Deficient in the Alpha/Beta Interferon Receptor
has PubMed Central identifier	PMC2663843
has PubMed identifier	19357779
schema:publication	PLoS One
resource representing a document's body	covid:9a9f7135f8ea0664e278c913bc12bb1413b09d4c#body_text
is schema:about of	named entity 'receptor' named entity 'severe' named entity 'BTV' named entity 'INFECTION' named entity 'LUNG' named entity 'RECOVERED' named entity 'ADDITION' named entity 'STARTING' named entity 'THYMUS' named entity 'IMMUNE RESPONSE' named entity '48 HOURS' named entity 'DISCHARGES' named entity 'adult' named entity 'caused' named entity 'complete' named entity 'highly' named entity 'virus' named entity 'data' named entity 'IFNAR' named entity 'Bluetongue' named entity 'studies' named entity 'virus' named entity 'thymus' named entity 'pathogenesis' named entity 'Bluetongue' named entity 'pathogenesis' named entity 'mouse model' named entity 'IFNAR' named entity 'spleen' named entity 'vaccination' named entity 'administered intravenously' named entity 'Infection' named entity 'Bluetongue Virus' named entity 'Mice' named entity 'IFNAR' named entity 'plaque assay' named entity 'cell growth' named entity 'IFNAR' named entity 'virus' named entity 'virulence' named entity 'measles virus' named entity 'virus' named entity 'immunobiology' named entity 'Secreted' named entity 'virulence' named entity 'virus' named entity 'disease symptoms' named entity 'IFNAR' named entity 'virus replication' named entity 'antibody' named entity 'Orbivirus' named entity 'RT-qPCR' named entity 'spleen' named entity 'PBS' named entity 'Mediterranean Basin' named entity 'NS2' named entity 'viral titers' named entity 'animal model' named entity 'Tween 20' named entity 'virulence' named entity 'Histological' named entity 'genomes' named entity 'infection' named entity 'mouse model' named entity 'biting midges' named entity 'virus' named entity 'IFNAR' named entity 'type I IFN' named entity 'IFNAR' named entity 'IFNAR' named entity 'inoculation' named entity 'immune responses' named entity 'vaccinia virus' named entity 'capsid' named entity 'viral infection' named entity 'laboratory animal' named entity 'animal model'

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