About: Expression of Cystic Fibrosis Transmembrane Conductance Regulator in Ganglia of Human Gastrointestinal Tract

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About: Expression of Cystic Fibrosis Transmembrane Conductance Regulator in Ganglia of Human Gastrointestinal Tract Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Expression of Cystic Fibrosis Transmembrane Conductance Regulator in Ganglia of Human Gastrointestinal Tract
Creator	Guo, Yong Gu, Jiang Huang, Jin Korteweg, Christine Gu, Huan Qiu, Yamei Xue, Ruiqi
source	PMC
abstract	CF is caused by mutations of the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) which is an anion selective transmembrane ion channel that mainly regulates chloride transport, expressed in the epithelia of various organs. Recently, we have demonstrated CFTR expression in the brain, the spinal cord and the sympathetic ganglia. This study aims to investigate the expression and distribution of CFTR in the ganglia of the human gastrointestinal tract. Fresh tissue and formalin-fixed paraffin-embedded normal gastrointestinal tract samples were collected from eleven surgical patients and five autopsy cases. Immunohistochemistry, in situ hybridization, laser-assisted microdissection and nested reverse transcriptase polymerase chain reaction were performed. Expression of CFTR protein and mRNA was detected in neurons of the ganglia of all segments of the human gastrointestinal tract examined, including the stomach, duodenum, jejunum, ileum, cecum, appendix, colon and rectum. The extensive expression of CFTR in the enteric ganglia suggests that CFTR may play a role in the physiology of the innervation of the gastro-intestinal tract. The presence of dysfunctional CFTRs in enteric ganglia could, to a certain extent, explain the gastrointestinal symptoms frequently experienced by CF patients.
has issue date	2016-08-05(xsd:dateTime)
bibo:doi	10.1038/srep30926
bibo:pmid	27491544
has license	cc-by
sha1sum (hex)	9a13ccd6be3536af404c25e748c34eac997c5d16
schema:url	https://doi.org/10.1038/srep30926
resource representing a document's title	Expression of Cystic Fibrosis Transmembrane Conductance Regulator in Ganglia of Human Gastrointestinal Tract
has PubMed Central identifier	PMC4974654
has PubMed identifier	27491544
schema:publication	Sci Rep
resource representing a document's body	covid:9a13ccd6be3536af404c25e748c34eac997c5d16#body_text
is schema:about of	named entity 'expression' named entity 'sympathetic ganglia' named entity 'Fresh' named entity 'situ' named entity 'FRESH TISSUE' named entity 'STOMACH' named entity 'SYMPATHETIC GANGLIA' named entity 'SAMPLES' named entity 'NEURONS' named entity 'CECUM' named entity 'COLLECTED' named entity 'ORGANS' named entity 'OPEN' named entity 'PROTEIN ' named entity 'PHYSIOLOGY' named entity 'SELECTIVE' named entity 'EXPERIENCED' named entity 'CFTR' named entity 'DISTRIBUTION' named entity 'COLON' covid:arg/9a13ccd6be3536af404c25e748c34eac997c5d16 named entity 'CERTAIN' named entity 'MRNA' named entity 'ION CHANNEL' named entity 'SEGMENTS' named entity 'MICRODISSECTION ' named entity 'AUTOPSY' named entity 'INCLUDING' named entity 'CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR' named entity 'EXPRESSION' named entity 'EXPRESSED' named entity 'NESTED' named entity 'ANION' named entity 'GASTROINTESTINAL TRACT' named entity 'STUDY' named entity 'FREQUENTLY' named entity 'THE BRAIN' named entity 'ILEUM' named entity 'GASTROINTESTINAL TRACT' named entity 'EXPRESSION' named entity 'SURGICAL PATIENTS' named entity 'HUMAN' named entity 'ENTERIC' named entity 'DUODENUM' named entity 'DEMONSTRATED' named entity 'APPENDIX' named entity 'EXAMINED' named entity 'ROLE' named entity 'ENCODING' named entity 'DETECTED' named entity 'NORMAL' named entity 'JEJUNUM' named entity 'PLAY' named entity 'PERFORMED' named entity 'GASTRO-INTESTINAL' named entity 'INTESTINAL TRACT' named entity 'HAVE' named entity 'RECENTLY' named entity 'VARIOUS' named entity 'GASTROINTESTINAL SYMPTOMS' named entity 'CHLORIDE TRANSPORT' named entity 'INNERVATION' named entity 'TRANSMEMBRANE' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'CASES' named entity 'CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR' named entity 'PRESENCE OF' named entity 'MUTATIONS' named entity 'SPINAL CORD' named entity 'EXTENT' named entity 'CAUSED BY' named entity 'IN SITU HYBRIDIZATION' named entity 'TO INVESTIGATE' named entity 'DYSFUNCTIONAL' named entity 'GENE'

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