About: INHIBITORY EFFECT OF EMODIN ON RAW 264.7 ACTIVATED WITH DOUBLE STRANDED RNA ANALOGUE POLY I:C

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	INHIBITORY EFFECT OF EMODIN ON RAW 264.7 ACTIVATED WITH DOUBLE STRANDED RNA ANALOGUE POLY I:C
Creator	Kim, Young-Jin Park, Wansu An, Hyo-Jin Choi, You-Kyung Kim, Do-Hoon Kim, Hyun-Ju Kim, Jaieun Lee, Hye Lee, Ji Lee, Tae Kang, Mi
Source	Medline; PMC
abstract	BACKGROUND: Emodin (3-methyl-1, 6, 8-trihydroxyanthraquinone) is a compound which can be found in Polygoni Multiflori Radix (PMR). PMR is the root of Polygonum multiflorum. PMR is used to treat dizziness, spermatorrhea, sores, and scrofula as well as chronic malaria traditionally in China and Korea. The anti-tumor property of emodin was already reported. However, anti-viral activity of emodin on macrophages are not fully reported. MATERIALS AND METHODS: Effects of emodin on RAW 264.7 mouse macrophages induced by polyinosinic-polycytidylic acid (poly I:C), a synthetic analog of double-stranded RNA, were evaluated. RESULTS: Emodin restored the cell viability in poly I: C-induced RAW 264.7 at concentrations of up to 50 μM. Emodin significantly inhibited the production of nitric oxide, IL-1α, IL-Ιβ, IL-6, GM-CSF, G-CSF, M-CSF, MCP-1, MIP-1a, MIP-Ιβ, MIP-2, RANTES, and IP-10 as well as calcium release and mRNA expression of signal transducer and activated transcription 1 (STAT1) in poly I:C-induced RAW 264.7 (P < 0.05). CONCLUSION: This study shows the inhibitory effect of emodin on poly I: C-induced RAW 264.7 via calcium-STAT pathway.
has issue date	2017-03-01(xsd:dateTime)
bibo:doi	10.21010/ajtcam.v14i3.17
bibo:pmid	28480427
has license	no-cc
sha1sum (hex)	992c7e3cd0a143b2506bcbe51d1cda024fb5b526
schema:url	https://doi.org/10.21010/ajtcam.v14i3.17
resource representing a document's title	INHIBITORY EFFECT OF EMODIN ON RAW 264.7 ACTIVATED WITH DOUBLE STRANDED RNA ANALOGUE POLY I:C
has PubMed Central identifier	PMC5412221
has PubMed identifier	28480427
schema:publication	Afr J Tradit Complement Altern Med
resource representing a document's body	covid:992c7e3cd0a143b2506bcbe51d1cda024fb5b526#body_text
is schema:about of	named entity 'PMR' named entity 'poly' named entity 'RAW' named entity 'RNA' named entity 'traditionally' named entity 'Emodin' named entity 'viability' named entity 'STAT' named entity 'PMR' named entity 'M-CSF' named entity 'RESULTS' named entity '283' named entity 'FULLY' named entity 'THE CELL' named entity 'POLYINOSINIC-POLYCYTIDYLIC ACID' named entity 'BCM' named entity 'INHIBITED' named entity 'CHINA' named entity 'RAW 264.7' named entity 'A COMPOUND' named entity 'REPORTED' named entity 'SYNTHETIC' named entity 'PROPERTY' named entity 'MACROPHAGES' named entity 'MIP-2' named entity 'TRANSCRIPTION' named entity 'PATHWAY' named entity 'MOUSE' named entity 'VIRAL ACTIVITY' named entity 'EFFECTS' named entity 'IL-6' named entity 'POLY I' named entity 'FOUND' named entity 'MATERIALS' named entity 'KOREA' named entity 'CALCIUM' named entity 'CELL VIABILITY' named entity 'IS A' named entity 'METHYL' named entity 'NITRIC OXIDE' named entity 'DOUBLE-STRANDED RNA' named entity 'GM-CSF' named entity 'MRNA EXPRESSION' named entity 'CONCLUSION' named entity 'TREAT' named entity '28P' named entity 'PRODUCTION' named entity 'RANTES' named entity 'G-CSF' named entity 'POLY I' named entity 'INHIBITORY EFFECT' named entity 'ACTIVATED' named entity 'ANALOGUE' named entity 'UP TO' named entity 'IP-10' named entity 'INDUCED' named entity 'TRIHYDROXYANTHRAQUINONE' named entity 'TUMOR' named entity 'EVALUATED' named entity 'MCP-1' named entity 'POLYGONI MULTIFLORI RADIX' named entity 'CHRONIC MALARIA' named entity 'STUDY' named entity 'RAW 264.7' named entity 'IL-1' named entity 'SCROFULA' named entity 'ANALOG' named entity 'SIGNAL TRANSDUCER' named entity 'BACKGROUND' named entity 'CALCIUM RELEASE' named entity 'POLYGONUM MULTIFLORUM'

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