About: Modulation of type I interferon induction by porcine reproductive and respiratory syndrome virus and degradation of CREB-binding protein by non-structural protein 1 in MARC-145 and HeLa cells

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About: Modulation of type I interferon induction by porcine reproductive and respiratory syndrome virus and degradation of CREB-binding protein by non-structural protein 1 in MARC-145 and HeLa cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Modulation of type I interferon induction by porcine reproductive and respiratory syndrome virus and degradation of CREB-binding protein by non-structural protein 1 in MARC-145 and HeLa cells
Creator	Sun, Yan Yoo, Dongwan Kim, Oekyung Song, Cheng Lai, Frances
Source	Elsevier; Medline; PMC
abstract	Abstract Porcine reproductive and respiratory syndrome (PRRS) is an emerged disease of swine characterized by negligible response of type I IFNs and viral persistence. We show that the PRRSV non-structural protein 1 (Nsp1) is the viral component responsible for modulation of IFN response. Nsp1 blocked dsRNA-induced IRF3 and IFN promoter activities. Nsp1 did not block phosphorylation and nuclear translocation of IRF3 but inhibited IRF3 association with CREB-binding protein (CBP) in the nucleus. While IRF3 was stable, CBP was degraded, and CBP degradation was proteasome-dependent, suggesting that CBP degradation is not due to the protease activity of Nsp1 but an intermediary is involved. Our data suggest that the Nsp1-mediated CBP degradation inhibits the recruitment of CBP for enhanceosome assembly, leading to the block of IFN response. CBP degradation is a novel strategy for viral evasion from the host response, and Nsp1 may form a new class of viral antagonists for IFN modulation.
has issue date	2010-07-05(xsd:dateTime)
bibo:doi	10.1016/j.virol.2010.03.039
bibo:pmid	20416917
has license	els-covid
sha1sum (hex)	974c4f87ddd8d6f25467e6b1ddc61e9739005581
schema:url	https://doi.org/10.1016/j.virol.2010.03.039
resource representing a document's title	Modulation of type I interferon induction by porcine reproductive and respiratory syndrome virus and degradation of CREB-binding protein by non-structural protein 1 in MARC-145 and HeLa cells
has PubMed Central identifier	PMC7157927
has PubMed identifier	20416917
schema:publication	Virology
resource representing a document's body	covid:974c4f87ddd8d6f25467e6b1ddc61e9739005581#body_text
is schema:about of	named entity 'TYPE I INTERFERON' named entity 'type I IFNs' named entity 'blocked' named entity 'type I interferon' named entity 'Modulation' named entity 'HOST RESPONSE' named entity 'BLOCK' named entity 'DATA' named entity 'BLOCKED' named entity 'PRRSV' named entity 'BUT' named entity 'INDUCED' named entity 'NOVEL' named entity 'DEGRADED' named entity 'MODULATION' named entity 'INTERMEDIARY' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME' named entity 'STABLE' named entity 'ASSEMBLY' named entity 'PROTEIN ' named entity 'NUCLEAR TRANSLOCATION' named entity 'SWINE' named entity 'CHARACTERIZED' named entity 'MEDIATED' named entity 'NEW' named entity 'FORM' named entity 'PROMOTER' named entity 'DUE TO' named entity 'RESPONSIBLE' named entity 'DSRNA' named entity 'INVOLVED' named entity 'SUGGEST' named entity 'NSP1' named entity 'DEGRADATION' named entity 'ACTIVITIES' named entity 'RECRUITMENT' named entity 'CBP' named entity 'DEPENDENT' named entity 'ASSOCIATION' named entity 'CLASS' named entity 'NEGLIGIBLE' named entity 'IRF3' named entity 'DISEASE' named entity 'STRATEGY' named entity 'ENHANCEOSOME' named entity 'NON-STRUCTURAL PROTEIN 1' named entity 'CREB-BINDING PROTEIN' named entity 'NUCLEUS' named entity 'RESPONSE' named entity 'OUR' named entity 'MODULATION' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'DEGRADATION' named entity 'INDUCTION' named entity 'MARC' named entity 'HELA CELLS' named entity 'INTERFERON ' named entity 'DID' named entity 'INHIBITED' named entity 'IS A' named entity 'PROTEASE ACTIVITY' named entity 'PHOSPHORYLATION' named entity 'VIRAL COMPONENT' named entity 'PROTEASOME' named entity 'LEADING' named entity 'IFN' named entity 'VIRAL PERSISTENCE' named entity 'ANTAGONISTS' named entity 'VIRAL' named entity 'PROTEIN ' named entity 'NON-STRUCTURAL PROTEIN 1' named entity 'CREB-BINDING PROTEIN' named entity '145' named entity 'TYPE I' covid:arg/974c4f87ddd8d6f25467e6b1ddc61e9739005581 named entity 'data' named entity 'CBP'

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