About: Bubble bilevel ventilation facilitates gas exchange in anesthetized rabbits

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bubble bilevel ventilation facilitates gas exchange in anesthetized rabbits
Creator	Smith, Sue Barnett, Joseph Carr, Benjamin Church, Joseph Dick, Macdonald Gustafson, Peter John, Anna John, Stephen John, Sunil Mohammed, Azmath Perkins, Elena Mcleod, Jennifer
Source	PMC
abstract	BACKGROUND: Bubble continuous positive airway pressure is an established therapy for infants in respiratory distress. In resource-limited settings, few treatment options exist for infants requiring further respiratory support. A bubble bilevel device has been developed to provide nonelectric, time-cycled, pressure-limited respiratory support. We compared the efficacy of bubble bilevel ventilation with conventional mechanical ventilation in sedated rabbits. METHODS: Six adult rabbits under inhaled isoflurane general anesthesia were ventilated by alternating intervals of conventional and bubble bilevel ventilation for three 10−15-min periods. During each period, interval arterial blood gas (ABG) measurements were obtained after at least 10 min on the respective mode of ventilation. RESULTS: The bubble bilevel system was able to deliver the following pressures: 20/7, 15/5, 12/5, 8/5 cm H(2)O. The estimated differences in arterial blood gas values on bubble bilevel vs. ventilator were as follows (normalized values): pH 7.41 vs. 7.40, pCO(2) 37.7 vs. 40, pO(2) 97.6 vs. 80. In addition, the bubble bilevel ventilation delivered consistent pressure waveforms without interruption for over 60 min on two rabbits. CONCLUSION: This study demonstrates promising in vivo results on the efficacy of a novel bubble bilevel device, which may prove useful for infants in respiratory distress. IMPACT: Given the lack of personnel, funds or infrastructure to provide neonatal mechanical ventilation in resource-limited settings, additional low-cost, low-tech treatments are necessary to save infant lives. Bubble bilevel ventilation reliably delivers two levels of airway pressure to anesthetized rabbits resulting in normalization of blood gases comparable to those achieved on a traditional ventilator. If proven effective, simple technologies like this device have the potential to significantly impact neonatal mortality due to respiratory distress globally.
has issue date	2020-05-01(xsd:dateTime)
bibo:doi	10.1038/s41390-020-0928-0
bibo:pmid	32357365
has license	no-cc
sha1sum (hex)	96658b921c405bc0855d80076066acb6d1e77a3c
schema:url	https://doi.org/10.1038/s41390-020-0928-0
resource representing a document's title	Bubble bilevel ventilation facilitates gas exchange in anesthetized rabbits
has PubMed Central identifier	PMC7223040
has PubMed identifier	32357365
schema:publication	Pediatr Res
resource representing a document's body	covid:96658b921c405bc0855d80076066acb6d1e77a3c#body_text
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