About: The effect of smoking on influenza, influenza vaccination efficacy and on the antibody response to influenza vaccination

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About: The effect of smoking on influenza, influenza vaccination efficacy and on the antibody response to influenza vaccination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The effect of smoking on influenza, influenza vaccination efficacy and on the antibody response to influenza vaccination
Creator	Aretz, Karin Thijs, Carel Cruij, Mark Dinant, Jan Govaert, Theo®el Knottnerus, Andreâ
source	Elsevier; Medline; PMC
abstract	Abstract We examined the relation between cigarette smoking and (1) the occurrence of influenza, (2) the efficacy of influenza vaccination and (3) the antibody response to influenza vaccination in fifteen family practices in South-Limburg, the Netherlands, during the influenza season 1991–1992. Data were used from a randomized double-blind placebo-controlled trial into the efficacy of influenza vaccination in which smoking status was measured 10 weeks after the start of the trial. A total of 1838 subjects aged 60 years or older, of whom 1531 subjects (321 smokers, 1152 non-smokers and 58 cigar/pipe smokers) who returned the smoking questionnaire and were not previously vaccinated, were used in the analyses. The main outcome measures were serological influenza (fourfold increase of antibody titre between 3 weeks and 5 months after vaccination); clinical influenza as determined by criteria of the Dutch Sentinel Stations from self reported symptoms in postal questionnaires 10 weeks and 5 months after vaccination; increases after vaccination and decreases after 5 months in logarithmic titres of antibody against the vaccine strains. No relation between smoking and either serological or clinical influenza was found, although the risk for serological influenza was slightly (not significantly) elevated in smokers compared to non-smokers. A statistical interaction was found between smoking and vaccination when serological influenza was the outcome measure indicating that the efficacy of vaccination was greater in smokers than in non-smokers (comparison of model with and without interaction; likelihood ratio test, p<0.0001). This finding is supported by a greater titre rise 3 weeks after vaccination for two out of four strains, but not by the antibody response after vaccination in previous studies on influenza and other infectious diseases. Also, this possible difference of immunogenicity is not reflected in a better protection for clinical influenza. The rise in antibody titre 3 weeks after vaccination was higher in smokers for A/Singapore/6/86 and B/Beijing/11/87, but not for the other two strains. Decline in titres after 5 months was similar for smokers and non-smokers. We conclude that smoking has no clinical or preventive significance for risk of influenza in the elderly.
has issue date	1999-02-28(xsd:dateTime)
bibo:doi	10.1016/s0264-410x(98)00213-8
bibo:pmid	10073719
has license	els-covid
sha1sum (hex)	9630b95696daa16ef7377ab2fb1373b4cdf86058
schema:url	https://doi.org/10.1016/s0264-410x%2898%2900213-8
resource representing a document's title	The effect of smoking on influenza, influenza vaccination efficacy and on the antibody response to influenza vaccination
has PubMed Central identifier	PMC7130566
has PubMed identifier	10073719
schema:publication	Vaccine
resource representing a document's body	covid:9630b95696daa16ef7377ab2fb1373b4cdf86058#body_text
is schema:about of	named entity 'serological' named entity 'titre' named entity 'serological' named entity 'response' named entity 'VACCINATION' named entity 'BUT' named entity 'ANTIBODY' named entity 'CLINICAL' named entity 'SMOKING STATUS' named entity 'MODEL' named entity 'MAIN' named entity 'ELDERLY' named entity 'VACCINATED' named entity 'ANTIBODY RESPONSE' named entity 'OCCURRENCE' named entity 'PREVIOUS' named entity 'SOUTH' named entity 'FOUND' named entity 'SUBJECTS' named entity 'TITRE' named entity 'COMPARED' named entity 'INTERACTION' named entity 'QUESTIONNAIRE' named entity 'RISK' named entity 'YEARS' named entity 'SMOKERS' named entity 'SIMILAR' named entity 'STATISTICAL' named entity 'SEROLOGICAL' named entity 'OTHER INFECTIOUS DISEASES' named entity 'STRAINS' named entity 'QUESTIONNAIRES' named entity '1152' named entity 'HIGHER' named entity 'INCREASE' named entity 'ANTIBODY TITRE' named entity 'PREVIOUSLY' named entity 'TEST' named entity 'INDICATING' covid:arg/9630b95696daa16ef7377ab2fb1373b4cdf86058 named entity 'MONTHS' named entity 'POSSIBLE' named entity 'OUTCOME MEASURES' named entity 'SUBJECTS AGED' named entity 'SLIGHTLY' named entity 'PROTECTION' named entity 'DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL' named entity 'NON-SMOKERS' named entity 'IMMUNOGENICITY' named entity 'PREVENTIVE' named entity '10 WEEKS' named entity 'DUTCH' named entity 'EITHER' named entity 'LOGARITHMIC' named entity 'CRITERIA' named entity 'RANDOMIZED' named entity 'TOTAL' named entity 'DATA' named entity '1531' named entity 'SENTINEL' named entity 'SYMPTOMS' named entity 'USED' named entity 'ELEVATED' named entity 'POSTAL' named entity 'RISE' named entity 'RISK OF' named entity 'DETERMINED BY' named entity 'DECLINE' named entity 'RESPONSE TO' named entity '283' named entity 'DECREASES' named entity 'START' named entity '28321' named entity 'SMOKING' named entity 'SUPPORTED' named entity 'EXAMINED'

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