About: Spike gene deletion quasispecies in serum of patient with acute MERS‐CoV infection

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About: Spike gene deletion quasispecies in serum of patient with acute MERS‐CoV infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Spike gene deletion quasispecies in serum of patient with acute MERS‐CoV infection
Creator	Al-Masri, Malak Assiri, Abdullah Lu, Xiaoyan Watson, John Erdman, Dean Abedi, Glen Stevens, James Frace, Michael Banassir, Taleb Elnile, Osman Rowe, Lori
Source	Medline; PMC
abstract	The spike glycoprotein of the Middle East respiratory coronavirus (MERS‐CoV) facilitates receptor binding and cell entry. During investigation of a multi‐facility outbreak of MERS‐CoV in Taif, Saudi Arabia, we identified a mixed population of wild‐type and variant sequences with a large 530 nucleotide deletion in the spike gene from the serum of one patient. The out of frame deletion predicted loss of most of the S2 subunit of the spike protein leaving the S1 subunit with an intact receptor binding domain. This finding documents human infection with a novel genetic variant of MERS‐CoV present as a quasispecies. J. Med. Virol. 89:542–545, 2017. © 2016 Wiley Periodicals, Inc.
has issue date	2016-08-22(xsd:dateTime)
bibo:doi	10.1002/jmv.24652
bibo:pmid	27486688
has license	no-cc
sha1sum (hex)	960b5b04f20b09537c42408c937cb60a7ca176b3
schema:url	https://doi.org/10.1002/jmv.24652
resource representing a document's title	Spike gene deletion quasispecies in serum of patient with acute MERS‐CoV infection
has PubMed Central identifier	PMC7166981
has PubMed identifier	27486688
schema:publication	J Med Virol
resource representing a document's body	covid:960b5b04f20b09537c42408c937cb60a7ca176b3#body_text
is schema:about of	named entity 'respiratory' named entity 'genetic variant' named entity 'intact' named entity 'MERS-CoV' named entity 'Deletion' named entity 'CELL' named entity 'SERUM' named entity 'VARIANT' named entity 'leaving' named entity 'cell' named entity 'outbreak' named entity 'Taif' named entity 'spike' named entity 'subunit' named entity 'serum' named entity 'dipeptidyl peptidase-4' named entity 'spike protein' named entity 'MERS-CoV' named entity 'wild-type' named entity 'human infection' named entity 'MERS-CoV' named entity 'wild-type' named entity 'Taif' named entity 'serum' named entity 'receptor binding domain' named entity 'Gene Deletion' named entity 'gene' named entity 'epidemiologically' named entity 'tested positive' named entity 'MERS-CoV' named entity 'Sanger sequencing' named entity 'virus' named entity 'protease' named entity 'membrane fusion' named entity 'protein' named entity 'virus' named entity 'MERS-CoV' named entity 'MERS-CoV' named entity 'virus' named entity 'protein' named entity 'spike protein' named entity 'macrophages' named entity 'DPP4' named entity 'feline coronavirus' named entity 'neutralizing antibodies' named entity 'virus' named entity 'Saudi Arabia' named entity 'intracellular' named entity 'serum samples' named entity 'Sanger sequencing' named entity 'SF6' named entity 'titer' named entity 'furin' named entity 'protease' named entity 'virus entry' named entity 'Sequencher' named entity 'fusion peptide' named entity 'antibodies' named entity 'genome sequencing' named entity 'gene deletion' named entity 'cell receptor' named entity 'Makkah Region' named entity 'coronaviruses' named entity 'virus' named entity 'membrane fusion' named entity 'PacBio' named entity 'genome sequences' named entity 'human coronaviruses' named entity 'Saudi Arabia' named entity 'in-frame' named entity 'genomic variants'

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