About: Characterization of BIV Env core: Implication for mechanism of BIV-mediated cell fusion

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About: Characterization of BIV Env core: Implication for mechanism of BIV-mediated cell fusion Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of BIV Env core: Implication for mechanism of BIV-mediated cell fusion
Creator	Tien, Po Li, Shu Gao, George Cui, Shanshan Peng, Yu Wang, Chunping Zhu, Jieqing
Source	Elsevier; Medline; PMC
abstract	Abstract Entry of lentiviruses, such as human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV), requires folding of two heptad repeat regions (HR1 and HR2) of gp41 into a trimer-of-hairpins, which subsequently brings virus and cell membrane into fusion. This motif is a generalized feature of viral fusion proteins and has been exploited in generating antiviral fusion agents. In the present paper, we report structural characters of Env protein from another lentivirus, bovine immunodeficiency virus (BIV), which contributes to a good animal model of HIV. BIV HR1 and HR2 regions are predicted by two different programs and expressed separately or conjointly in Escherichia coli. Biochemical and biophysical analyses show that the predicted HRs of BIV Env can form a stable trimer-of-hairpins or six-helix bundle just like that formed by feline immunodeficiency virus Env. Cell fusion assay demonstrates that the HR2 peptide of BIV can efficiently inhibit the virus-mediated cell fusion.
has issue date	2005-04-08(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2005.01.160
bibo:pmid	15737628
has license	els-covid
sha1sum (hex)	94c31275838b6ba8d2e8fc5b7e7504f573567695
schema:url	https://doi.org/10.1016/j.bbrc.2005.01.160
resource representing a document's title	Characterization of BIV Env core: Implication for mechanism of BIV-mediated cell fusion
has PubMed Central identifier	PMC7117376
has PubMed identifier	15737628
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:94c31275838b6ba8d2e8fc5b7e7504f573567695#body_text
is schema:about of	named entity 'MECHANISM' named entity 'Entry' named entity 'inhibit' named entity 'folding' named entity 'good' named entity 'expressed' named entity 'Env' named entity 'ENTRY' named entity 'LENTIVIRUS' named entity 'VIRUS' named entity 'REPORT' named entity 'PROTEIN ' named entity 'REGIONS' named entity 'HELIX' named entity 'HR2' named entity 'LENTIVIRUSES' named entity 'ESCHERICHIA COLI' named entity 'EXPRESSED' named entity 'CELL FUSION' named entity 'FELINE IMMUNODEFICIENCY VIRUS' named entity 'BIOPHYSICAL' named entity 'CHARACTERS' named entity 'CORE' named entity 'PAPER' named entity 'FEATURE' named entity 'ASSAY' named entity 'GENERALIZED' named entity 'ENV' named entity 'ENV' named entity 'VIRAL FUSION PROTEINS' named entity 'MEDIATED' named entity 'CHARACTERIZATION' named entity 'BIV' named entity 'MEDIATED' named entity 'PEPTIDE' named entity 'PREDICTED' named entity 'SIMIAN IMMUNODEFICIENCY VIRUS' named entity 'MODEL OF' named entity 'JUST' named entity 'REPEAT' named entity 'ANIMAL MODEL' named entity 'ENV PROTEIN' named entity 'BOVINE IMMUNODEFICIENCY VIRUS' named entity 'GENERATING' named entity 'FORMED' named entity 'PROGRAMS' named entity 'GOOD' named entity 'STRUCTURAL' named entity 'BUNDLE' named entity 'HIV' named entity 'HUMAN IMMUNODEFICIENCY VIRUS TYPE 1' named entity 'ANTIVIRAL' named entity 'DIFFERENT' named entity 'FOLDING' named entity 'HR1' named entity 'FORM' named entity 'TRIMER' named entity 'HRS' named entity 'GP41' named entity 'CELL MEMBRANE' named entity 'LIKE' named entity 'STABLE' named entity 'PRESENT' named entity 'OF-' named entity 'CELL FUSION' named entity 'FUSION' named entity 'MOTIF' named entity 'BIOCHEMICAL' named entity 'IS A' covid:arg/94c31275838b6ba8d2e8fc5b7e7504f573567695 named entity 'exploited' named entity 'motif' named entity 'separately' named entity 'HR1' named entity 'cell membrane'

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