About: The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts

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About: The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts
Creator	Cobacho, Nicole Costa, Fabrício Da Cunha, Nicolau Dias, Simoni Dohms, Stephan Ferreira, Arthur Franco, L Lima, Loiane Sampaio, Kamila Sar De La Fuente-Nú Ñ Ez, Cé Viana, Juliane Vio, Octá
Source	Elsevier; Medline; PMC
abstract	Anti-infective drugs have had a key role in the contemporary world, contributing to dramatically decrease mortality rates caused by infectious diseases worldwide. Antimicrobial peptides (AMPs) are multifunctional effectors of the innate immune system of mucosal surfaces and present antimicrobial activity against a range of pathogenic viruses, bacteria, and fungi. However, the discovery and development of new antibacterial drugs is a crucial step to overcome the great challenge posed by the emergence of antibiotic resistance. In this review, we outline recent advances in the development of novel AMPs with improved antimicrobial activities that were achieved through characteristic structural design. In addition, we describe recent progress made to overcome some of the major limitations that have hindered peptide biosynthesis.
has issue date	2016-11-23(xsd:dateTime)
bibo:doi	10.1016/j.drudis.2016.10.017
bibo:pmid	27890668
has license	no-cc
sha1sum (hex)	94b8609f8a41b304107199040676a79d59c0f461
schema:url	https://doi.org/10.1016/j.drudis.2016.10.017
resource representing a document's title	The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts
has PubMed Central identifier	PMC7185764
has PubMed identifier	27890668
schema:publication	Drug Discov Today
resource representing a document's body	covid:94b8609f8a41b304107199040676a79d59c0f461#body_text
is schema:about of	named entity 'DISEASES' named entity 'ANTIMICROBIAL' named entity 'PROVIDES' named entity 'DEVELOPMENT' named entity 'RECENT' named entity 'REVIEW' named entity 'MOLECULAR' named entity 'ECONOMIC IMPACTS' named entity 'TOOLS' named entity 'ANTIMICROBIAL' named entity 'BIOSYNTHESIS' named entity 'PEPTIDES' named entity 'THERAPEUTIC' named entity 'TREATMENT' named entity 'GENERATION' named entity 'PEPTIDES' named entity 'SCENARIO' named entity 'RELEVANT' named entity 'SOURCES' named entity 'INTEGRATED' named entity 'PROVIDED' named entity 'DESIGN' named entity 'STRUCTURAL' named entity 'USEFUL' named entity 'NATURAL' named entity 'DRUGS' named entity 'SOCIAL' named entity 'biosynthesis' named entity 'antimicrobial peptides' named entity 'structural design' named entity 'antimicrobial peptides' named entity 'AMPs' named entity 'vancomycin' named entity 'gene' named entity 'antimicrobial activity' named entity 'AMPs' named entity 'cell wall' named entity 'phosphate groups' named entity 'intracellular' named entity 'peptide' named entity 'Gleba' named entity 'pentapeptide' named entity 'cationic' named entity 'translocation' named entity 'post-translational modifications' named entity 'protein' named entity 'AMP' named entity 'lipid' named entity 'natural products' named entity 'peptide-based' named entity 'biosynthesis' named entity 'peptides' named entity 'AlmE' named entity 'bacteria' named entity 'biologically active' named entity 'DARPA' named entity 'bacteria' named entity 'Biofilm' named entity 'glycosylated' named entity 'bacteria' named entity 'bacteria' named entity 'gene silencing' named entity 'cationic' named entity 'peptides' named entity 'AMPs' named entity 'cell death' named entity 'EPS' named entity 'flu' named entity 'amino acid residue' named entity 'evolutionary pressure'

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