About: Candidemia in immunocompromised and immunocompetent critically ill patients: a prospective comparative study

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About: Candidemia in immunocompromised and immunocompetent critically ill patients: a prospective comparative study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Candidemia in immunocompromised and immunocompetent critically ill patients: a prospective comparative study
Creator	Dimopoulos, G Falagas, M Karabinis, A Samonis, G
Source	PMC
abstract	The purpose of this study was to compare the risk factors, clinical manifestations, and outcome of candidemia in immunocompromised (IC) and nonimmunocompromised (NIC) critically ill patients. Data were collected prospectively over a 2-year period (02/2000–01/2002) from patients in a 25-bed, medical–surgical intensive care unit (ICU). Eligible for participation in this study were patients who developed candidemia during their ICU stay. Patients under antifungal therapy and with a confirmed systemic fungal infection prior to the diagnosis of candidemia were excluded. Cultures of blood, urine, and stool were performed for all patients in the study, and all patients underwent endoscopy/biopsy of the esophagus for detection of Candida. Smears and/or scrapings of oropharyngeal and esophageal lesions were examined for hyphae and/or pseudohyphae and were also cultured for yeasts. During the study period, 1,627 patients were hospitalized in the ICU, 57% for primary medical reasons and 43% for surgical reasons. After application of the study’s inclusion and exclusion criteria, 24 patients with candidemia (9 IC and 15 NIC) were analyzed. Total parenteral nutrition was more common in IC than in NIC patients (9/9 [100%] vs 8/15 [53%], p = 0.02). Oropharyngeal candidiasis was detected in 5 of 9 (55.5%) IC patients and in 1 of 15 (6.5%) NIC patients (p = 0.015). Esophageal candidiasis was also more common in IC than in NIC patients (4/9 [44%] vs 0/15 [0%], p = 0.012). Among the 9 IC patients, all except 2 died, resulting in a crude mortality of 78%; among the 15 NIC patients, 9 died, resulting in a crude mortality of 60% (p > 0.05). Autopsy was performed in two IC and in six NIC patients, with disseminated candidiasis found in one IC patient. Oropharyngeal and esophageal candidiasis are frequent in IC patients with candidemia. In contrast, this coexistence is rare in NIC critically ill patients with Candida bloodstream infections. A high mortality was noted in both IC and NIC critically ill patients with candidemia.
has issue date	2007-05-25(xsd:dateTime)
bibo:doi	10.1007/s10096-007-0316-2
bibo:pmid	17525857
has license	no-cc
sha1sum (hex)	9396d61cd7f362ab076c9e58d54e2d96bd768a21
schema:url	https://doi.org/10.1007/s10096-007-0316-2
resource representing a document's title	Candidemia in immunocompromised and immunocompetent critically ill patients: a prospective comparative study
has PubMed Central identifier	PMC7101586
has PubMed identifier	17525857
schema:publication	Eur J Clin Microbiol Infect Dis
resource representing a document's body	covid:9396d61cd7f362ab076c9e58d54e2d96bd768a21#body_text
is schema:about of	named entity 'exclusion criteria' named entity 'mortality' named entity 'performed' named entity 'surgical' named entity 'DATA' named entity 'DETECTED' named entity 'PARTICIPATION' named entity 'MEDICAL REASONS' named entity 'SURGICAL' named entity 'THEIR' named entity 'RISK FACTORS' named entity '27S' named entity 'BLOOD' named entity 'HOSPITALIZED' named entity 'DISSEMINATED CANDIDIASIS' named entity 'PSEUDOHYPHAE' named entity 'PATIENT' covid:arg/9396d61cd7f362ab076c9e58d54e2d96bd768a21 named entity 'oropharyngeal' named entity 'compare' named entity 'patients' named entity 'period' named entity 'Cultures' named entity 'patients' named entity 'patients' named entity 'candidiasis' named entity 'detected' named entity 'candidemia' named entity 'application' named entity 'Patients' named entity 'patients' named entity 'performed' named entity 'Candida' named entity 'primary' named entity 'therapy' named entity 'Candida' named entity 'died' named entity 'study' named entity 'patient' named entity 'esophagus' named entity 'immunocompromised' named entity 'Esophageal candidiasis' named entity 'immunocompromised' named entity 'Candida' named entity 'candidemia' named entity 'risk factors' named entity 'critically ill patients' named entity 'endoscopy' named entity 'critically ill patients' named entity 'candidemia' named entity '4/9' named entity 'Oropharyngeal candidiasis' named entity 'Autopsy' named entity 'ICU' named entity 'candidemia' named entity 'immunocompromised' named entity 'pseudohyphae' named entity 'Autopsy' named entity 'critically ill patients' named entity 'ICU' named entity 'alcoholic cirrhosis' named entity 'leukaemia' named entity 'ICU' named entity 'diabetes' named entity 'inflammatory' named entity 'Candida spp' named entity 'septic shock' named entity 'critical illness' named entity 'infection' named entity 'Candida spp' named entity 'histological examination' named entity 'mucosal' named entity 'critically ill patients' named entity 'bloodstream' named entity 'candidemia' named entity 'Candida spp' named entity 'Candida spp' named entity 'pancreatitis'

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