About: In vivo cytokine response to experimental feline infectious peritonitis virus infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In vivo cytokine response to experimental feline infectious peritonitis virus infection
Creator	Olivry, Thierry Stanton, Christine Dean, Gregg Pedersen, Niels
Source	Elsevier; Medline; PMC
abstract	Feline infectious peritonitis virus (FIPV) is a coronavirus that causes sporadic fatal disease in cats characterized by vasculitis, granulomatous inflammation and effusive pleuritis/peritonitis. Histologic changes in lymphoid tissues include lymphoid hyperplasia, lymphoid depletion, histiocytosis, and granuloma formation. Although viremia occurs, histologic lesions are not found uniformly throughout lymphoid tissues. We used experimental infection of cats with a highly pathogenic FIPV isolate, UCD8, to study histologic lesions, virus replication, and cytokine expression in multiple lymphoid tissues during the effusive phase of disease. Viral RNA was found in 76% of central tissues (mediastinal lymph node, spleen, mesenteric lymph node) examined, as compared to 27% of peripheral tissues (popliteal lymph node, cervical lymph node, femoral bone marrow). All tissues positive for virus replication also demonstrated lymphoid depletion. Generally, affected tissues had lower levels of IL-4 and IL-12–p40 mRNA and higher levels of IL-10 mRNA. Although no differences in IFN-γ or TNF-α mRNA were measured, TNF-α protein expression was greater in affected tissues and demonstrated a shift in the source of TNF-α from macrophages to lymphocytes. Together, these results colocalize FIPV replication, lymphocyte depletion in tissues, and alterations in cytokine transcription and translation. A possible role for TNF-α in the previously described FIPV-induced lymphocyte apoptosis is also suggested.
has issue date	2003-12-02(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2003.08.010
bibo:pmid	14637034
has license	no-cc
sha1sum (hex)	9360b24fdb94f1c2ffa3ee7416c7f86b9d6e6661
schema:url	https://doi.org/10.1016/j.vetmic.2003.08.010
resource representing a document's title	In vivo cytokine response to experimental feline infectious peritonitis virus infection
has PubMed Central identifier	PMC7117329
has PubMed identifier	14637034
schema:publication	Vet Microbiol
resource representing a document's body	covid:9360b24fdb94f1c2ffa3ee7416c7f86b9d6e6661#body_text
is schema:about of	named entity 'replication' named entity 'demonstrated' named entity 'isolate' named entity 'All' named entity 'Although' named entity 'p40' named entity 'tissues' named entity 'effusive' named entity 'In vivo' named entity 'HIGHER' named entity 'TNF-' named entity 'VIRUS INFECTION' named entity 'LYMPHOID HYPERPLASIA' named entity 'CHANGES' named entity 'INCLUDE' named entity 'IS A' named entity 'SHIFT' named entity 'TRANSCRIPTION' named entity 'MESENTERIC LYMPH NODE' named entity 'PLEURITIS' named entity 'FEMORAL BONE' named entity 'LYMPHOCYTE DEPLETION' named entity 'INDUCED' named entity 'FELINE INFECTIOUS PERITONITIS VIRUS' named entity 'P40' named entity 'CYTOKINE ' named entity 'CERVICAL LYMPH NODE' named entity 'SPLEEN' named entity 'TISSUES' named entity 'MULTIPLE' named entity 'PROTEIN EXPRESSION' named entity 'POSITIVE FOR' named entity 'LEVELS' named entity 'FOUND' named entity 'EXPERIMENTAL' named entity 'IFN' named entity '90%' named entity 'LYMPHOCYTES' named entity 'CYTOKINE ' named entity 'RESPONSE TO' named entity 'FELINE INFECTIOUS PERITONITIS VIRUS' named entity 'IN VIVO' named entity 'SOURCE' named entity 'CORONAVIRUS' named entity 'POSSIBLE' named entity 'PATHOGENIC' named entity 'GENERALLY' named entity 'BONE MARROW' named entity 'MEASURED' named entity 'SPORADIC' named entity 'LOWER' named entity 'VIRAL RNA' named entity 'IL-4' named entity 'ALTERATIONS' named entity 'FATAL DISEASE' named entity 'GRANULOMATOUS INFLAMMATION' named entity 'NOT FOUND' named entity 'COMPARED' named entity 'AFFECTED' named entity 'IL-10' named entity 'THESE' named entity 'VASCULITIS' named entity 'LYMPHOID DEPLETION' named entity 'LYMPHOID TISSUES' named entity 'USED' named entity 'HISTOLOGIC' named entity 'CHARACTERIZED' named entity 'ALL TISSUES' named entity 'GREATER' named entity 'STUDY' named entity 'GRANULOMA FORMATION' named entity 'DEMONSTRATED' named entity 'TRANSLATION' named entity 'MRNA' named entity 'PREVIOUSLY' named entity 'IL-12' named entity 'LESIONS' named entity 'PERIPHERAL'

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