About: Fatal pneumonia and viremia due to human parainfluenza virus type 1 in a patient with adult T-cell leukemia

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About: Fatal pneumonia and viremia due to human parainfluenza virus type 1 in a patient with adult T-cell leukemia–lymphoma treated with mogamulizumab Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Fatal pneumonia and viremia due to human parainfluenza virus type 1 in a patient with adult T-cell leukemia–lymphoma treated with mogamulizumab
Creator	Aoyama, Hajime Fujita, Jiro Fukushima, Takuya Hanashiro, Taeko Kinjo, Takeshi Masuzaki, Hiroaki Morichika, Kazuho Nakachi, Sawako Nishi, Yukiko Shimabukuro, Natsuki Taira, Naoya Tamaki, Keita Tedokon, Iori Tomoyose, Takeaki Yoshimi, Naoki
source	Elsevier; Medline; PMC
abstract	Abstract We report a case of fatal pneumonia and viremia due to human parainfluenza virus type 1 (HPIV-1) in a 65-year-old male patient with adult T-cell leukemia–lymphoma (ATL) treated with mogamulizumab, a brand-new therapeutic agent for ATL. To our knowledge, this is the first report describing viremia due to HPIV-1. After administering mogamulizumab, lymphocyte count in the blood was drastically decreased and the patient suffered from complicated infections including gram-negative bacterial sepsis, cytomegalovirus antigenemia and aspergillosis. Although these infections were successfully controlled by broad spectrum antimicrobial therapy, patchy ground-grass opacities in the both lungs were gradually worsened. He finally died due to acute respiratory failure. Since findings of the chest CT was consistent with typical patterns of viral pneumonia, we screened major respiratory viruses in the peripheral blood with multiplex PCR, and it turned out that RNA of HPIV-1 was positive. Although ATL cells were not detected in the autopsied lungs and a variety of other tissues, cytoplasmic inclusion bodies, which are commonly observed in RNA viral infection, were abundantly observed in the autopsied lung tissue. These findings suggest that mogamulizumab accomplished complete remission of ATL, while the chemotherapy-induced prolonged lymphopenia caused fatal pneumonia and viremia due to HPIV-1. As it has been well recognized that community respiratory viruses including HPIV-1 often cause fatal pneumonia in patients with leukemia, but also there is no specific treatment for HPIV-1, we have to enforce standard precautions especially when we treat leukemic patients with intensively immunosuppressive agents such as mogamulizumab.
has issue date	2015-11-30(xsd:dateTime)
bibo:doi	10.1016/j.jiac.2015.07.001
bibo:pmid	26231316
has license	els-covid
sha1sum (hex)	9205667cdec5ab68e043b62502652139f5418056
schema:url	https://doi.org/10.1016/j.jiac.2015.07.001
resource representing a document's title	Fatal pneumonia and viremia due to human parainfluenza virus type 1 in a patient with adult T-cell leukemia–lymphoma treated with mogamulizumab
has PubMed Central identifier	PMC7129467
has PubMed identifier	26231316
schema:publication	Journal of Infection and Chemotherapy
resource representing a document's body	covid:9205667cdec5ab68e043b62502652139f5418056#body_text
is schema:about of	named entity 'acute respiratory failure' named entity 'RNA' named entity 'patterns' named entity 'viremia' named entity 'Since' named entity 'opacities' named entity 'detected' named entity 'died' named entity 'viruses' covid:arg/9205667cdec5ab68e043b62502652139f5418056 named entity 'T-cell' named entity 'lungs' named entity 'HPIV-1' named entity 'screened' named entity 'Although' named entity 'viral pneumonia' named entity 'sepsis' named entity 'cytoplasmic inclusion' named entity 'observed' named entity 'gram-negative' named entity 'recognized' named entity 'inclusion bodies' named entity 'intensively' named entity 'blood' named entity 'mogamulizumab' named entity 'acute respiratory failure' named entity 'pneumonia' named entity 'complete remission' named entity 'cytomegalovirus' named entity 'broad spectrum' named entity 'type 1' named entity 'lung tissue' named entity 'chest CT' named entity 'aspergillosis' named entity 'RNA' named entity 'HPIV-1' named entity 'type 1' named entity 'human parainfluenza virus' named entity 'mogamulizumab' named entity 'T-cell' named entity 'HPIV-1' named entity 'long-term' named entity 'syncytial' named entity 'bacterial pneumonia' named entity 'antibodies' named entity 'HPIV-1' named entity 'bronchiolitis' named entity 'viral pneumonia' named entity 'RNA' named entity 'peripheral blood' named entity 'giant cells' named entity 'RNA virus' named entity 'HPIV-1' named entity 'enterovirus' named entity 'LDH' named entity 'protein' named entity 'WBC' named entity 'mogamulizumab' named entity 'lymphopenia' named entity 'lymphoma' named entity 'adenovirus' named entity 'antimicrobial' named entity 'HPIV-1' named entity 'formalin' named entity 'mogamulizumab' named entity 'acute myocarditis' named entity 'inclusion bodies'

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