About: COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus

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About: COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus
Creator	Zdrenghea, Mihnea Santos, Dos Maria, • Rambaldi, Alessandro Delgado, Julio Foà, Robin Jose, • Rossi, Davide Yassin, Mohamed Andres, Martin Bron, Dominique Chatzikonstantinou, Thomas Chiarenza, Annalisa Coscia, Marta Cuneo, Antonio Cuéllar-García, Carolina Dimou, Maria Enrico, Alicia Ferrari, Angela Foglietta, Myriam Ghia, Paolo Gian, • Gimeno, Eva Janssens, Ann Kalashnikova, Olga Kersting, Sabina Lista, Enrico Marasca, Roberto Marquet, Juan Mauro, Francesca Mirás, Fatima Motta, Marina Munir, Talha Nikitin, Eugene Papaioannou, Maria Pocali, Barbara Quaresmini, Giulia Rossi, Giuseppe Ruchlemer, Rosa Scarfò, Lydia Shah, Nimish Shrestha, Amit Sportoletti, Paolo Stamatopoulos, Kostas Strugov, Vladimir Vandenberghe, Elisabeth Vitale, Candida Wasik-Szczepanek, Ewa Arnon, • Carsten, • Cuneo, • De Paolis, Rosaria Der Spek, Van Doubek, • Ellen, • Emili' Montserrat, • Farina, • Francesca, • Gabor Barna, • Garcia-Marco, Antonio Gianluigi, • Gilad, • Gimena, • Giovanni, • Gr, Kostas Kater, P Lara Malerba, • Laurenti, • Levin, • Mark-David Livio Trentin, • Lorella Orsucci, • Lorenzo, • Macarena, • Marchetti, • Marzia Varettoni, • Massimo Gentile, • Mónica Baile, • Niemann, U Oana Stanca, • Ozren, • Paoli, De Pareja, Ortiz Poeta, Del Popov, Maria Quaglia, Maria Rigolin, Matteo Stavroyianni, • Sunil Iyengar, • Tam, • Tobias, • Viola, • Yair Herishanu, • Yervand, •
Source	Medline; PMC
abstract	Chronic lymphocytic leukemia (CLL) is a disease of the elderly, characterized by immunodeficiency. Hence, patients with CLL might be considered more susceptible to severe complications from COVID-19. We undertook this retrospective international multicenter study to characterize the course of COVID-19 in patients with CLL and identify potential predictors of outcome. Of 190 patients with CLL and confirmed COVID-19 diagnosed between 28/03/2020 and 22/05/2020, 151 (79%) presented with severe COVID-19 (need of oxygen and/or intensive care admission). Severe COVID-19 was associated with more advanced age (≥65 years) (odds ratio 3.72 [95% CI 1.79–7.71]). Only 60 patients (39.7%) with severe COVID-19 were receiving or had recent (≤12 months) treatment for CLL at the time of COVID-19 versus 30/39 (76.9%) patients with mild disease. Hospitalization rate for severe COVID-19 was lower (p < 0.05) for patients on ibrutinib versus those on other regimens or off treatment. Of 151 patients with severe disease, 55 (36.4%) succumbed versus only 1/38 (2.6%) with mild disease; age and comorbidities did not impact on mortality. In CLL, (1) COVID-19 severity increases with age; (2) antileukemic treatment (particularly BTK inhibitors) appears to exert a protective effect; (3) age and comorbidities did not impact on mortality, alluding to a relevant role of CLL and immunodeficiency.

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