About: Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites
Creator	Welsch, Sonja Bartenschlager, Ralf Krijnse-Locker, Jacomine Antony, Claude Merz, Andreas Walther, Paul Miller, Sven Romero-Brey, Ines Bleck, Christopher Fuller, Stephen
Source	Elsevier; Medline; PMC
abstract	Positive-strand RNA viruses are known to rearrange cellular membranes to facilitate viral genome replication. The biogenesis and three-dimensional organization of these membranes and the link between replication and virus assembly sites is not fully clear. Using electron microscopy, we find Dengue virus (DENV)-induced vesicles, convoluted membranes, and virus particles to be endoplasmic reticulum (ER)-derived, and we detect double-stranded RNA, a presumed marker of RNA replication, inside virus-induced vesicles. Electron tomography (ET) shows DENV-induced membrane structures to be part of one ER-derived network. Furthermore, ET reveals vesicle pores that could enable release of newly synthesized viral RNA and reveals budding of DENV particles on ER membranes directly apposed to vesicle pores. Thus, DENV modifies ER membrane structure to promote replication and efficient encapsidation of the genome into progeny virus. This architecture of DENV replication and assembly sites could explain the coordination of distinct steps of the flavivirus replication cycle.
has issue date	2009-04-23(xsd:dateTime)
bibo:doi	10.1016/j.chom.2009.03.007
bibo:pmid	19380115
has license	no-cc
sha1sum (hex)	8f706b5ee6fb8d199def52178e332826e457c190
schema:url	https://doi.org/10.1016/j.chom.2009.03.007
resource representing a document's title	Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites
has PubMed Central identifier	PMC7103389
has PubMed identifier	19380115
schema:publication	Cell Host Microbe
resource representing a document's body	covid:8f706b5ee6fb8d199def52178e332826e457c190#body_text
is schema:about of	named entity 'viruses' named entity 'Thus' named entity 'link' named entity 'sites' named entity 'membranes' named entity 'ASSEMBLY' named entity 'STEPS' named entity 'ENCAPSIDATION' named entity 'USING' named entity 'VIRUS PARTICLES' named entity 'STRAND' named entity 'SITES' named entity 'COMPOSITION' named entity 'COORDINATION' named entity 'RNA REPLICATION' named entity 'ER MEMBRANE' named entity 'DENGUE VIRUS' named entity 'VIRAL RNA' named entity 'PART OF' named entity 'DENGUE VIRUS' named entity 'VIRUS REPLICATION' named entity 'ELECTRON MICROSCOPY' named entity 'MEMBRANE STRUCTURES' named entity 'REPLICATION CYCLE' named entity 'SITES' named entity 'VESICLE' named entity 'SYNTHESIZED' named entity 'DIRECTLY' named entity 'VIRAL GENOME REPLICATION' named entity 'ENDOPLASMIC RETICULUM' named entity 'RELEASE' named entity 'FLAVIVIRUS' named entity 'DOUBLE-STRANDED RNA' named entity 'EFFICIENT' named entity 'VIRUS ASSEMBLY' named entity 'NEWLY' named entity 'MEMBRANES' named entity 'RNA VIRUSES' named entity 'GENOME' named entity 'POSITIVE' named entity 'ARCHITECTURE' named entity 'MARKER' named entity 'KNOWN' named entity 'REPLICATION' named entity 'PRESUMED' named entity 'VESICLES' named entity 'MODIFIES' named entity 'ARCHITECTURE' named entity 'THREE-DIMENSIONAL' named entity 'DISTINCT' named entity 'ENABLE' named entity 'PARTICLES' named entity 'CONVOLUTED' named entity 'CELLULAR' named entity 'REVEALS' named entity 'PROGENY' named entity 'BIOGENESIS' named entity 'ASSEMBLY' named entity 'CLEAR' named entity 'VIRUS' named entity 'LINK' named entity 'INDUCED' named entity 'ELECTRON TOMOGRAPHY' named entity 'THREE-DIMENSIONAL' named entity 'MEMBRANE STRUCTURE' named entity 'NETWORK' named entity 'ORGANIZATION' named entity 'THESE' named entity 'ER-' named entity 'DERIVED' named entity 'BUDDING' named entity 'PROMOTE'

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