About: The Nucleoprotein and Phosphoprotein of Peste des Petits Ruminants Virus Inhibit Interferons Signaling by Blocking the JAK-STAT Pathway

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About: The Nucleoprotein and Phosphoprotein of Peste des Petits Ruminants Virus Inhibit Interferons Signaling by Blocking the JAK-STAT Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Nucleoprotein and Phosphoprotein of Peste des Petits Ruminants Virus Inhibit Interferons Signaling by Blocking the JAK-STAT Pathway
Creator	Li, Linlin Nan, Yuchen Wu, Chunyan Zheng, Haixue Li, Pengfei Xue, Qinghong Dang, Wen Du, Xiaoli Liu, Xiangtao Zhang, Miaotao Zhang, Xiangle Zhu, Zixiang
Source	Medline; PMC
abstract	Peste des petits ruminants virus (PPRV) is associated with global peste des petits ruminants resulting in severe economic loss. Peste des petits ruminants virus dampens host interferon-based signaling pathways through multiple mechanisms. Previous studies deciphered the role of V and C in abrogating IFN-β production. Moreover, V protein directly interacted with signal transducers and activators of transcription 1 (STAT1) and STAT2 resulting in the impairment of host IFN responses. In our present study, PPRV infection inhibited both IFN-β- and IFN-γ-induced activation of IFN-stimulated response element (ISRE) and IFN-γ-activated site (GAS) element, respectively. Both N and P proteins, functioning as novel IFN response antagonists, markedly suppressed IFN-β-induced ISRE and IFN-γ-induced GAS promoter activation to impair downstream upregulation of various interferon-stimulated genes (ISGs) and prevent STAT1 nuclear translocation. Specifically, P protein interacted with STAT1 and subsequently inhibited STAT1 phosphorylation, whereas N protein neither interacted with STAT1 nor inhibited STAT1 phosphorylation as well as dimerization, suggesting that the N and P protein antagonistic effects were different. Though they differed in their relationship to STAT1, both proteins blocked JAK-STAT signaling, severely negating the host antiviral immune response. Our study revealed a new mechanism employed by PPRV to evade host innate immune response, providing a platform to study the interaction of paramyxoviruses and host response.
has issue date	2019-07-08(xsd:dateTime)
bibo:doi	10.3390/v11070629
bibo:pmid	31288481
has license	cc-by
sha1sum (hex)	8e7aa7140ee7e3c82c78c1aa4cf0cb2583e8d9bd
schema:url	https://doi.org/10.3390/v11070629
resource representing a document's title	The Nucleoprotein and Phosphoprotein of Peste des Petits Ruminants Virus Inhibit Interferons Signaling by Blocking the JAK-STAT Pathway
has PubMed Central identifier	PMC6669484
has PubMed identifier	31288481
schema:publication	Viruses
resource representing a document's body	covid:8e7aa7140ee7e3c82c78c1aa4cf0cb2583e8d9bd#body_text
is schema:about of	named entity 'prevent' named entity 'phosphorylation' named entity 'STAT2' named entity 'response' named entity 'interacted' named entity 'site' named entity 'blocked' named entity 'antiviral' named entity 'protein' named entity 'protein' named entity 'IFN-β' named entity 'host' named entity 'Nucleoprotein' named entity 'JAK-STAT Pathway' named entity 'INTERFERONS' named entity 'MULTIPLE' covid:arg/8e7aa7140ee7e3c82c78c1aa4cf0cb2583e8d9bd named entity 'MECHANISM' named entity 'ELEMENT' named entity 'SIGNAL' named entity 'PLATFORM' named entity 'PESTE DES PETITS RUMINANTS VIRUS' named entity 'NUCLEOPROTEIN' named entity 'NOVEL' named entity 'INFECTION' named entity 'IMPAIRMENT' named entity 'BLOCKED' named entity 'VARIOUS' named entity 'PATHWAY' named entity 'JAK' named entity 'PESTE DES PETITS RUMINANTS VIRUS' named entity 'TRANSCRIPTION' named entity 'ACTIVATED' named entity 'ECONOMIC LOSS' named entity 'PROTEINS' named entity 'PROTEIN ' named entity 'SIGNALING PATHWAYS' named entity 'INNATE IMMUNE RESPONSE' named entity 'N PROTEIN' named entity 'RESPONSE' named entity 'STIMULATED' named entity 'PROVIDING' named entity 'FUNCTIONING' named entity 'THEIR' named entity 'PHOSPHOPROTEIN' named entity 'JAK' named entity 'SIGNALING' named entity 'SEVERELY' named entity 'ROLE' named entity 'P PROTEIN' named entity 'HOST RESPONSE' named entity 'EMPLOYED' named entity 'DIMERIZATION' named entity 'SUPPRESSED' named entity 'DIFFERENT' named entity 'SITE' named entity 'GLOBAL' named entity 'STAT1' named entity 'INTERACTION' named entity 'PREVENT' named entity 'UPREGULATION' named entity 'RELATIONSHIP' named entity 'PRESENT' named entity 'PESTE DES PETITS RUMINANTS' named entity 'SEVERE' named entity 'INDUCED' named entity 'PRODUCTION' named entity 'RESPONSES' named entity 'NEITHER' named entity 'RESULTING IN'

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