About: Impact of COVID-19 on liver function: results from an internal medicine unit in Northern Italy

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About: Impact of COVID-19 on liver function: results from an internal medicine unit in Northern Italy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Impact of COVID-19 on liver function: results from an internal medicine unit in Northern Italy
Creator	Baldanti, Fausto Antonio, · Aronico, Nicola Borrelli De Andreis, Federica Cococcia, Sara Corazza, Roberto Delliponti, Mariangela Di, Michele Gino, · Klersy, Catherine Lenti, Marco Melazzini, Federica Mengoli, · Merli, Stefania Miceli, Emanuela Pellegrino, Ivan Pinzani, Massimo Sabatino, Di Santacroce, Giovanni Soriano, Simone Triarico, Antonio
source	Medline; PMC
abstract	Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function in 100 COVID-19 consecutive patients (median age 70 years, range 25–97; 79 males) who were admitted to our internal medicine unit in March 2020. We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome. A patient was considered as having liver injury when alanine aminotransferase (ALT) was > 50 mU/ml, gamma-glutamyl transpeptidase (GGT) > 50 mU/ml, or total bilirubin > 1.1 mg/dl. Spearman correlation coefficient for laboratory data and bivariable analysis for mortality and/or need for intensive care were assessed. A minority of patients (18.6%) were obese, and most patients were non- or moderate-drinkers (88.5%). Liver function tests were altered in 62.4% of patients, and improved during follow-up. None of the seven patients with known chronic liver disease had liver decompensation. Only one patient developed acute liver failure. In patients with altered liver function tests, PaO(2)/FiO(2) < 200 was associated with greater mortality and need for intensive care (HR 2.34, 95% CI 1.07–5.11, p = 0.033). To conclude, a high prevalence of altered liver function tests was noticed in Italian patients with COVID-19, and this was associated with worse outcomes when developing severe acute respiratory distress syndrome. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11739-020-02425-w) contains supplementary material, which is available to authorized users.
has issue date	2020-07-10(xsd:dateTime)
bibo:doi	10.1007/s11739-020-02425-w
bibo:pmid	32651938
has license	cc-by
sha1sum (hex)	8d14e91e2601c6e1d07c52f864c7fe96e5119626
schema:url	https://doi.org/10.1007/s11739-020-02425-w
resource representing a document's title	Impact of COVID-19 on liver function: results from an internal medicine unit in Northern Italy
has PubMed Central identifier	PMC7348571
has PubMed identifier	32651938
schema:publication	Intern Emerg Med
resource representing a document's body	covid:8d14e91e2601c6e1d07c52f864c7fe96e5119626#body_text
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