About: SARS-CoV-2 infection protects against rechallenge in rhesus macaques

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About: SARS-CoV-2 infection protects against rechallenge in rhesus macaques Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-CoV-2 infection protects against rechallenge in rhesus macaques
Creator	Baric, Ralph Abbink, Peter Andersen, Hanne Nityanandam, Ramya Alter, Galit Yu, Jingyou Lifton, Michelle Liu, Jinyan Lewis, Mark Miller, Andrew Tostanoski, Lisa Barouch, Dan Estes, Jacob He, Xuan Burke, John Sorger, Peter Atyeo, Caroline Blade, Kelvin Bondzie, Esther Brown, Renita Busman-Sahay, Kathleen Chandrashekar, Abishek Cook, Anthony Dagotto, Gabriel Ducat, Sarah Fischinger, Stephanie Finneyfrock, Brad Gebre, Makda Greenhouse, Jack Jacob-Dolan, Catherine Kordana, Nicole Li, Zhenfeng Mahrokhian, Shant Maliga, Zoltan Martinez, David Martinot, Amanda Maxfield, Lori Mcmahan, Katherine Mercado, Noe Nekorchuk, Michael Nkolola, Joseph Pessaint, Laurent Peter, Lauren Ry, Alex Schmidt, Aaron Slein, Matthew Taylor, Tammy Teow, Elyse Terry, Margaret Velasco, Jason Wegmann, Frank Wrijil, Linda Zahn, Roland
Source	Medline; PMC
abstract	An understanding of protective immunity to SARS-CoV-2 is critical for vaccine and public health strategies aimed at ending the global COVID-19 pandemic. A key unanswered question is whether infection with SARS-CoV-2 results in protective immunity against re-exposure. We developed a rhesus macaque model of SARS-CoV-2 infection and observed that macaques had high viral loads in the upper and lower respiratory tract, humoral and cellular immune responses, and pathologic evidence of viral pneumonia. Following initial viral clearance, animals were rechallenged with SARS-CoV-2 and showed 5 log(10) reductions in median viral loads in bronchoalveolar lavage and nasal mucosa compared with primary infection. Anamnestic immune responses following rechallenge suggested that protection was mediated by immunologic control. These data show that SARS-CoV-2 infection induced protective immunity against re-exposure in nonhuman primates.
has issue date	2020-05-20(xsd:dateTime)
bibo:doi	10.1126/science.abc4776
bibo:pmid	32434946
has license	cc-by
sha1sum (hex)	8cc1f70e6072a0b3da37792dd66a441c7faaeb45
schema:url	https://doi.org/10.1126/science.abc4776
resource representing a document's title	SARS-CoV-2 infection protects against rechallenge in rhesus macaques
has PubMed Central identifier	PMC7243369
has PubMed identifier	32434946
schema:publication	Science
resource representing a document's body	covid:8cc1f70e6072a0b3da37792dd66a441c7faaeb45#body_text
is schema:about of	named entity 'development' named entity 'developed' named entity 'COVID-19' named entity 'immunologic' named entity 'SPREAD' named entity 'SARS-COV-2 INFECTION' named entity 'INFECTION' named entity 'HUMANS' named entity 'NATURAL IMMUNITY' named entity 'DEVELOPMENT' named entity 'VIROLOGIC' named entity 'MODEL OF' named entity 'humans' named entity 'pandemic' named entity 'infection' named entity 'infection' named entity 'public health' named entity 'vaccine' named entity 'natural immunity' named entity 'infection' named entity 'SARS-CoV-2' named entity 'epithelial' named entity 'gene' named entity 'rechallenge' named entity 'nucleocapsid' named entity 'humoral' named entity 'virus' named entity 'virologic' named entity '1.1'

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