About: Multi‐season analyses of causative pathogens in children hospitalized with asthma exacerbation

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multi‐season analyses of causative pathogens in children hospitalized with asthma exacerbation
Creator	Hasegawa, Shunji Shirabe, Komei Wakiguchi, Hiroyuki Abe, Nozomi Fukano, Reiji Nakamura, \| Okada, Seigo Okamoto, Reiko Okazaki, Fumiko Ouchi, \| Shoichi Toda, \| Shouichi Ohga, \| Yasudo, Hiroki
Source	PMC
abstract	BACKGROUND: Respiratory viral and mycoplasma infections are associated with childhood asthma exacerbations. Here, we explored epidemiologic profile of causative pathogens and possible factors for exacerbation in a single center over a three‐year period. METHODS: Hospitalized asthmatic children with attack aged 6 months‐17 years were recruited between 2012 and 2015 (n = 216). Nasopharyngeal mucosa cell samples were collected from the participants and examined by reverse transcription‐polymerase chain reaction to detect rhinovirus (RV), respiratory syncytial virus (RSV), enterovirus (EV), parainfluenza virus (PIV), Mycoplasma pneumoniae, and others. Clinical features, laboratory data, asthma exacerbation intensity, and asthma severity were compared among participants. Epidemiologic profile of causative pathogens and possible factors for exacerbation were explored. RESULTS: Viruses and/or Mycoplasma pneumoniae were detected in 75% of the participants. Rhinovirus (48%) was the most commonly detected virus in the participants with single infection, followed by RSV (6%). The median age at admission in the RV group was significantly higher than that in the RSV group. Insufficient asthma control and allergen sensitization were significantly related to RV‐associated asthma exacerbation. There was no seasonality of pathogen types associated with asthma exacerbation although a sporadic prevalence of EV‐D68 was observehinovirud. Rhinovirus were repeatedly detected in multiple admission cases. CONCLUSION: Our three‐year analysis revealed that patients with RV infection were significantly prone to repeated RV infection in the subsequent exacerbation and good asthma control could prevent RV‐associated asthma development and exacerbation. Multiple‐year monitoring allowed us to comprehend the profile of virus‐ and/or mycoplasma‐induced asthma exacerbation.
has issue date	2019-08-12(xsd:dateTime)
bibo:doi	10.1111/pai.13102
bibo:pmid	31251831
has license	no-cc
sha1sum (hex)	8b259cbee94cece15bf41eb299c8ae82c18b90d2
schema:url	https://doi.org/10.1111/pai.13102
resource representing a document's title	Multi‐season analyses of causative pathogens in children hospitalized with asthma exacerbation
has PubMed Central identifier	PMC7167852
has PubMed identifier	31251831
schema:publication	Pediatr Allergy Immunol
resource representing a document's body	covid:8b259cbee94cece15bf41eb299c8ae82c18b90d2#body_text
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