About: Innate Immune Responses in ALV-J Infected Chicks and Chickens with Hemangioma In Vivo

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About: Innate Immune Responses in ALV-J Infected Chicks and Chickens with Hemangioma In Vivo Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Innate Immune Responses in ALV-J Infected Chicks and Chickens with Hemangioma In Vivo
Creator	Li, Zhenhui Feng, Min Shi, Meiqing Xie, Tingting Zhang, Xiquan Dai, Manman Kawana-Tachikawa, Ai Ueno, Takamasa Adachi, Akio Cheng, Japan University, Kumamoto
Source	PMC
abstract	Avian leukosis virus subgroup J (ALV-J) infection can cause tumors and immunosuppression. Since the precise mechanism of the innate immune response induced by ALV-J is unknown, we investigated the antiviral innate immune responses induced by ALV-J in chicks and chickens that had developed tumors. Spleen levels of interleukin-6 (IL-6), IL-10, IL-1β, and interferon-β (IFN-β) were not significantly different between the infected chick groups and the control groups from 1 day post hatch to 7 days post hatch. However, IL-6, IL-1β, and IFN-β protein levels in the three clinical samples with hemangiomas were dramatically increased compared to the healthy samples. In addition, the anti-inflammatory cytokine IL-10 increased sharply in two of three clinical samples. We also found a more than 20-fold up-regulation of ISG12-1 mRNA at 1 day post infection (d.p.i.) and a twofold up-regulation of ZC3HAV1 mRNA at 4 d.p.i. However, there were no statistical differences in ISG12-1 and ZC3HAV1 mRNA expression levels in the tumorigenesis phase. ALV-J infection induced a significant increase of Toll-like receptor 7 (TLR-7) at 1 d.p.i. and dramatically increased the mRNA levels of melanoma differentiation-associated gene 5 (MDA5) in the tumorigenesis phase. Moreover, the protein levels of interferon regulatory factor 1 (IRF-1) and signal transducer and activator of transcription 1 (STAT1) were decreased in chickens with tumors. These results suggest that ALV-J was primarily recognized by chicken TLR7 and MDA5 at early and late in vivo infection stages, respectively. ALV-J strain SCAU-HN06 did not induce any significant antiviral innate immune response in 1 week old chicks. However, interferon-stimulated genes were not induced normally during the late phase of ALV-J infection due to a reduction of IRF1 and STAT1 expression.
has issue date	2016-05-25(xsd:dateTime)
bibo:doi	10.3389/fmicb.2016.00786
bibo:pmid	27252695
has license	cc-by
sha1sum (hex)	8b221945f093d8d13835556a56c2a1d8f02e2705
schema:url	https://doi.org/10.3389/fmicb.2016.00786
resource representing a document's title	Innate Immune Responses in ALV-J Infected Chicks and Chickens with Hemangioma In Vivo
has PubMed Central identifier	PMC4879323
has PubMed identifier	27252695
schema:publication	Front Microbiol
resource representing a document's body	covid:8b221945f093d8d13835556a56c2a1d8f02e2705#body_text
is schema:about of	named entity 'tumors' named entity 'Toll-like receptor' named entity 'However' named entity 'IFN-β' named entity 'Hemangioma' covid:arg/8b221945f093d8d13835556a56c2a1d8f02e2705 named entity 'infection' named entity 'melanoma' named entity 'mRNA' named entity 'antiviral' named entity 'IRF1' named entity 'tumors' named entity 'cytokine' named entity 'induced' named entity 'phase' named entity 'mRNA' named entity 'week' named entity 'ALV' named entity 'IFN' named entity 'infection' named entity 'd.p.' named entity 'protein' named entity 'Toll-like receptor 7' named entity 'Spleen' named entity 'control groups' named entity 'tumors' named entity 'antiviral' named entity 'tumors' named entity 'MDA5' named entity 'IFN-β' named entity 'mRNA' named entity 'interferon-stimulated genes' named entity 'ALV' named entity 'Avian leukosis virus' named entity 'qRT-PCR' named entity 'hyperplasia' named entity 'tumorigenesis' named entity 'immune responses' named entity 'cell membranes' named entity 'animal welfare' named entity 'IFN-β' named entity 'SPF' named entity 'P values' named entity 'HIV-1' named entity 'STAT1' named entity 'ALV' named entity 'RT-PCR' named entity 'PBS' named entity 'transcriptome' named entity 'White Leghorn' named entity 'immunosuppression' named entity 'spleens' named entity 'supernatants' named entity 'gene' named entity 'SDS-PAGE' named entity 'Fisher Scientific' named entity 'cDNA' named entity 'PBS' named entity 'antiviral' named entity 'homogenates' named entity 'induce the expression' named entity 'chicken' named entity 'ALV' named entity 'JAK-STAT' named entity 'Shanghai' named entity 'inoculation' named entity 'innate immune' named entity 'spleens' named entity 'expression levels' named entity 'genome' named entity 'animal experiment'

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