About: A systems approach to understanding human rhinovirus and influenza virus infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A systems approach to understanding human rhinovirus and influenza virus infection
Creator	Adams, Rachel Bheda-Malge, Anjali Gelinas, Richard Kim, Taek-Kyun Lin, Yakang Sreekrishna, Koti Bascom, Charles Isfort, Robert Robinson, Michael Tiesman, Jay
Source	Elsevier; Medline; PMC
abstract	Abstract Human rhinovirus and influenza virus infections of the upper airway lead to colds and the flu and can trigger exacerbations of lower airway diseases including asthma and chronic obstructive pulmonary disease. Novel diagnostic and therapeutic targets are still needed to differentiate between the cold and the flu, since the clinical course of influenza can be severe while that of rhinovirus is usually more mild. In our investigation of influenza and rhinovirus infection of human respiratory epithelial cells, we used a systems approach to identify the temporally changing patterns of host gene expression from these viruses. After infection of human bronchial epithelial cells (BEAS-2B) with rhinovirus, influenza virus or co-infection with both viruses, we studied the time-course of host gene expression changes over three days. We modeled host responses to these viral infections with time and documented the qualitative and quantitative differences in innate immune activation and regulation.
has issue date	2015-12-31(xsd:dateTime)
bibo:doi	10.1016/j.virol.2015.08.014
bibo:pmid	26437235
has license	els-covid
sha1sum (hex)	89ce74b2f97a53d57f5a2be4eb8f869abe448ea8
schema:url	https://doi.org/10.1016/j.virol.2015.08.014
resource representing a document's title	A systems approach to understanding human rhinovirus and influenza virus infection
has PubMed Central identifier	PMC7111289
has PubMed identifier	26437235
schema:publication	Virology
resource representing a document's body	covid:89ce74b2f97a53d57f5a2be4eb8f869abe448ea8#body_text
is schema:about of	named entity 'INFLUENZA VIRUS' named entity 'VIRUS INFECTION' named entity 'HUMAN RHINOVIRUS' named entity 'APPROACH' named entity 'SYSTEMS' named entity 'UNDERSTANDING' named entity 'systems approach' named entity 'influenza virus' named entity 'infection' named entity 'apoptosis' named entity 'AKR1C3' named entity 'cell receptor' named entity 'cytokine' named entity 'interferon' named entity 'LAMC2' named entity 'interferon' named entity 'JAK2' named entity 'lymph nodes' named entity 'IRF1' named entity 'capsid' named entity 'influenza' named entity 'neutrophil' named entity 'apoptosis' named entity 'ACSS2' named entity 'LAMA3' named entity 'epithelial cell' named entity 'NOXA' named entity 'infection' named entity 'nucleotidase' named entity 'apoptosis' named entity 'IL-15' named entity 'epithelial cells' named entity 'purines' named entity 'CCL20' named entity 'apoptosis' named entity 'gene expression' named entity 'macrophages' named entity 'respiratory syncytial virus' named entity 'terpenoid' named entity 'interact' named entity 'monocytes' named entity 'intrinsic apoptosis' named entity 'JNK' named entity 'membrane attack complex' named entity 'RNA' named entity 'NF-κB' named entity 'infection' named entity 'cell types' named entity 'CXCL10' named entity 'interferon' named entity 'CXCL10' named entity 'mRNAs' named entity 'infection' named entity 'laminin' named entity 'melanoma' named entity 'differentially expressed' named entity 'data analysis' named entity 'epithelial cells' named entity 'innate immune' named entity 'toll-like receptor' named entity 'pathogens' named entity 'CXCL10' named entity 'ITGA5' named entity 'viruses' named entity 'infection' named entity 'rhinovirus' named entity 'influenza' named entity 'epithelial cells' named entity 'Rho GTPases' named entity 'complement' named entity 'STAT1' named entity 'IL8'

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