About: Protective efficacy of a broadly cross-reactive swine influenza DNA vaccine encoding M2e, cytotoxic T lymphocyte epitope and consensus H3 hemagglutinin

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About: Protective efficacy of a broadly cross-reactive swine influenza DNA vaccine encoding M2e, cytotoxic T lymphocyte epitope and consensus H3 hemagglutinin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Protective efficacy of a broadly cross-reactive swine influenza DNA vaccine encoding M2e, cytotoxic T lymphocyte epitope and consensus H3 hemagglutinin
Creator	Yu, Hai Huang, Meng Ma, Ji-Hong Tong, Guang-Zhi Wang, Bin Yang, Fu-Ru
topic	covid:891adb48f822d8e7f4749448ea5e2b4828c9aae5#this
source	Medline; PMC
abstract	BACKGROUND: Pigs have been implicated as mixing reservoir for the generation of new pandemic influenza strains, control of swine influenza has both veterinary and public health significance. Unlike human influenza vaccines, strains used for commercially available swine influenza vaccines are not regularly replaced, making the vaccines provide limited protection against antigenically diverse viruses. It is therefore necessary to develop broadly protective swine influenza vaccines that are efficacious to both homologous and heterologous virus infections. In this study, two forms of DNA vaccines were constructed, one was made by fusing M2e to consensus H3HA (MHa), which represents the majority of the HA sequences of H3N2 swine influenza viruses. Another was made by fusing M2e and a conserved CTL epitope (NP147-155) to consensus H3HA (MNHa). Their protective efficacies against homologous and heterologous challenges were tested. RESULTS: BALB/c mice were immunized twice by particle-mediated epidermal delivery (gene gun) with the two DNA vaccines. It was shown that the two vaccines elicited substantial antibody responses, and MNHa induced more significant T cell-mediated immune response than MHa did. Then two H3N2 strains representative of different evolutional and antigenic clusters were used to challenge the vaccine-immunized mice (homosubtypic challenge). Results indicated that both of the DNA vaccines prevented homosubtypic virus infections completely. The vaccines’ heterologous protective efficacies were further tested by challenging with a H1N1 swine influenza virus and a reassortant 2009 pandemic strain. It was found that MNHa reduced the lung viral titers significantly in both challenge groups, histopathological observation showed obvious reduction of lung pathogenesis as compared to MHa and control groups. CONCLUSIONS: The combined utility of the consensus HA and the conserved M2e and CTL epitope can confer complete and partial protection against homologous and heterologous challenges, respectively, in mouse model. This may provide a basis for the development of universal swine influenza vaccines.
has issue date	2012-06-27(xsd:dateTime)
bibo:doi	10.1186/1743-422x-9-127
bibo:pmid	22738661
has license	cc-by
sha1sum (hex)	891adb48f822d8e7f4749448ea5e2b4828c9aae5
schema:url	https://doi.org/10.1186/1743-422x-9-127
resource representing a document's title	Protective efficacy of a broadly cross-reactive swine influenza DNA vaccine encoding M2e, cytotoxic T lymphocyte epitope and consensus H3 hemagglutinin
has PubMed Central identifier	PMC3447699
has PubMed identifier	22738661
schema:publication	Virol J
resource representing a document's body	covid:891adb48f822d8e7f4749448ea5e2b4828c9aae5#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/891adb48f822d8e7f4749448ea5e2b4828c9aae5
is schema:about of	named entity 'CROSS-REACTIVE' named entity 'epitope' named entity 'MHa' named entity 'heterologous' named entity 'vaccines' named entity 'hemagglutinin' named entity 'CONSENSUS' named entity 'VETERINARY' named entity 'NECESSARY' named entity 'EPITOPE' named entity 'HEMAGGLUTININ' named entity 'INFLUENZA VACCINES' named entity 'RESERVOIR' named entity 'M2E' named entity 'PUBLIC HEALTH' named entity 'CTL' named entity 'GENERATION' named entity 'AVAILABLE' named entity 'PIGS' named entity 'THEIR' named entity 'MIXING' named entity 'FUSING' named entity 'CONTROL' named entity 'EFFICACY' named entity 'T LYMPHOCYTE EPITOPE' named entity 'PROVIDE' named entity 'NEW' named entity 'ENCODING' named entity 'SWINE INFLUENZA' named entity 'CYTOTOXIC T LYMPHOCYTE' named entity 'M2E' named entity 'HOMOLOGOUS' named entity 'TESTED' named entity 'STUDY' named entity 'VACCINES' named entity 'CONSERVED' named entity 'USED' named entity 'SWINE INFLUENZA' named entity 'LIMITED' named entity 'CONSENSUS' named entity 'REGULARLY' named entity 'STRAINS' named entity 'HAVE' named entity 'INFECTIONS' named entity 'H3N2' named entity 'PANDEMIC' named entity 'INFLUENZA' named entity 'PROTECTION' named entity 'VIRUS' named entity 'FORMS OF DNA' named entity 'INFLUENZA VIRUSES' named entity 'VIRUSES' named entity 'DIVERSE' named entity 'REPLACED' named entity 'CHALLENGES' named entity 'BACKGROUND' named entity 'DNA VACCINES' named entity 'SIGNIFICANCE' named entity 'HETEROLOGOUS' named entity 'HUMAN INFLUENZA' named entity 'MAJORITY' named entity 'DNA VACCINE' named entity 'SEQUENCES' named entity 'CONSTRUCTED' covid:arg/891adb48f822d8e7f4749448ea5e2b4828c9aae5 named entity 'Pigs' named entity 'homologous' named entity 'regularly' named entity 'broadly' named entity 'heterologous' named entity 'viruses' named entity 'vaccines' named entity 'vaccines' named entity 'H3N2'

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