About: Increased serum aminotransferase activity and clinical outcomes in Coronavirus disease 2019

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Increased serum aminotransferase activity and clinical outcomes in Coronavirus disease 2019
Creator	Gajendran, Mahesh Goyal, Hemant Perisetti, Abhilash Ramachandran, Preethi Chakraborti, Abhishek Narh, Joshua Ramachandran, )
Source	Elsevier; Medline; PMC
abstract	OBJECTIVE: Elevation of hepatic aminotransferases (aspartate aminotransferase [AST]/alanine aminotransferase [ALT]) is commonly noted among COVID-19 patients. It is unclear if they can predict the clinical outcomes among hospitalized COVID-19 patients. We aim to assess if elevations in AST/ALT were associated with poor outcomes in hospitalized COVID-19 patients. METHODS: We retrospectively evaluated hospitalized COVID-19 patients with clinically significant elevated aminotransferases (defined as >2 times upper limit of normal) and compared them with COVID-19 patients without an elevation in aminotransferases. RESULTS: The prevalence of elevation in AST/ALT was found to be 13.7% (20/145). The two groups were similar in baseline demographics, comorbidities, and the majority of laboratory tests. There was no difference in the mortality (50% vs. 36.8%, P=0.32) and median hospital stay (7 days vs. 7 days, P=0.78). However, there was a statistically significant increase in the rates of mechanical ventilation among elevated aminotransferases group compared to individuals without elevation (50% vs. 24%, P= 0.028). However, this difference was not observed after adjusting for inflammatory markers such as ferritin, lactate dehydrogenase (LDH), and lactic acid levels. CONCLUSION: Elevated aminotransferases among hospitalized COVID-19 patients is associated with higher rates of mechanical ventilation, but did not achieve statistical significance after controlling for inflammatory markers. Also, patients with elevated aminotransferases did not have higher rates of mortality or prolonged length of stay.
has issue date	2020-06-30(xsd:dateTime)
bibo:doi	10.1016/j.jceh.2020.06.009
bibo:pmid	32837096
has license	no-cc
sha1sum (hex)	88a7050abf4d38c033289510e808c164bdfe2910
schema:url	https://doi.org/10.1016/j.jceh.2020.06.009
resource representing a document's title	Increased serum aminotransferase activity and clinical outcomes in Coronavirus disease 2019
has PubMed Central identifier	PMC7326426
has PubMed identifier	32837096
schema:publication	J Clin Exp Hepatol
resource representing a document's body	covid:88a7050abf4d38c033289510e808c164bdfe2910#body_text
is schema:about of	named entity 'aim' named entity 'AST' named entity 'hepatic' named entity 'activity' named entity 'AMINOTRANSFERASE' named entity 'ELEVATION' covid:arg/88a7050abf4d38c033289510e808c164bdfe2910 named entity 'patients' named entity 'patients' named entity 'Journal' named entity 'aspartate aminotransferase' named entity 'alanine aminotransferase' named entity 'clinical outcomes' named entity 'Coronavirus disease 2019' named entity 'aminotransferase' named entity 'aminotransferases' named entity 'aminotransferases' named entity 'LDH' named entity 'statistical significance' named entity 'aminotransferases' named entity 'liver injury' named entity 'alcohol' named entity 'inflammatory markers' named entity 'small intestine' named entity 'corona virus' named entity 'hepatoxicity' named entity 'ACE-2' named entity 'COVID' named entity 'liver' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'liver function' named entity 'fever' named entity 'severe acute respiratory syndrome' named entity 'Armonk' named entity 'COVID' named entity 'bilirubin' named entity 'liver' named entity 'aminotransferases' named entity 'ACE-2' named entity 'liver enzymes' named entity 'liver disease' named entity 'CT scan' named entity 'myalgia' named entity 'COVID' named entity 'summary statistics' named entity 'C-reactive protein' named entity 'cytokine' named entity 'NSAIDs' named entity 'non-steroidal anti-inflammatory drugs' named entity 'ferritin' named entity 'COVID' named entity 'aminotransferases' named entity 'univariate analysis' named entity 'retrospective study' named entity 'retrospective study' named entity 'chronic liver disease' named entity 'aminotransferases' named entity 'AST' named entity 'chronic liver disease' named entity 'NSAIDs' named entity 'AST' named entity 'SARS-CoV' named entity 'white blood cell count' named entity 'viral entry' named entity 'mortality rates' named entity 'sample size' named entity 'African Americans' named entity 'mechanical ventilation' named entity 'hepatic' named entity 'pathogenesis' named entity 'retrospective study' named entity 'study population' named entity 'lymphocyte count' named entity 'COVID-19'

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