About: Genomic Dissection of an Icelandic Epidemic of Respiratory Disease in Horses and Associated Zoonotic Cases

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About: Genomic Dissection of an Icelandic Epidemic of Respiratory Disease in Horses and Associated Zoonotic Cases Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genomic Dissection of an Icelandic Epidemic of Respiratory Disease in Horses and Associated Zoonotic Cases
Creator	Robinson, Carl Holden, Matthew Waller, Andrew Parkhill, Julian Björnsdóttir, Sigríður Charbonneau, Amelia Gammeljord, Kristina Gunnarsson, Eggert Harris, Simon Sigurðardóttir, Ólöf Steward, Karen Svansson, Vilhjálmur Arl, Charbonneau Björnsdóttir, Citation Jr, Newton Kf, Steward Mtg, Holden Newton, J Sr, Harris
Source	Medline; PMC
abstract	Iceland is free of the major infectious diseases of horses. However, in 2010 an epidemic of respiratory disease of unknown cause spread through the country’s native horse population of 77,000. Microbiological investigations ruled out known viral agents but identified the opportunistic pathogen Streptococcus equi subsp. zooepidemicus (S. zooepidemicus) in diseased animals. We sequenced the genomes of 257 isolates of S. zooepidemicus to differentiate epidemic from endemic strains. We found that although multiple endemic clones of S. zooepidemicus were present, one particular clone, sequence type 209 (ST209), was likely to have been responsible for the epidemic. Concurrent with the epidemic, ST209 was also recovered from a human case of septicemia, highlighting the pathogenic potential of this strain. Epidemiological investigation revealed that the incursion of this strain into one training yard during February 2010 provided a nidus for the infection of multiple horses that then transmitted the strain to farms throughout Iceland. This study represents the first time that whole-genome sequencing has been used to investigate an epidemic on a national scale to identify the likely causative agent and the link to an associated zoonotic infection. Our data highlight the importance of national biosecurity to protect vulnerable populations of animals and also demonstrate the potential impact of S. zooepidemicus transmission to other animals, including humans.
has issue date	2017-08-01(xsd:dateTime)
bibo:doi	10.1128/mbio.00826-17
bibo:pmid	28765219
has license	cc-by
sha1sum (hex)	88713ea3e0023a1f7bd5092cdb724e9a23d66ff9
schema:url	https://doi.org/10.1128/mbio.00826-17
resource representing a document's title	Genomic Dissection of an Icelandic Epidemic of Respiratory Disease in Horses and Associated Zoonotic Cases
has PubMed Central identifier	PMC5539424
has PubMed identifier	28765219
schema:publication	mBio
resource representing a document's body	covid:88713ea3e0023a1f7bd5092cdb724e9a23d66ff9#body_text
is schema:about of	named entity 'observed' named entity 'identify' named entity 'rapid' named entity 'consistent' named entity 'industries' named entity 'identified' named entity 'epidemic' named entity 'scale' named entity 'clinical signs' named entity 'animals' named entity 'epidemic' named entity 'case' named entity 'viral' named entity 'strains' named entity 'impact' named entity 'OBSERVED' named entity 'RESPONSIBLE' named entity 'PRESENT' named entity 'APPLIED' named entity 'NATIVE' named entity 'IMPACT' named entity 'BAN' named entity 'SPEED' named entity 'STREPTOCOCCUS EQUI SUBSP. ZOOEPIDEMICUS' named entity 'IDENTIFY' named entity 'DIFFERENTIATE' named entity 'CLONES' named entity 'ENTIRE' named entity 'ALMOST' named entity 'INFECTION' named entity 'DATA' named entity 'SPREAD' covid:arg/88713ea3e0023a1f7bd5092cdb724e9a23d66ff9 named entity 'Iceland' named entity 'incursion' named entity 'February 2010' named entity 'zoonotic infection' named entity 'horse' named entity 'epidemic' named entity 'horses' named entity 'opportunistic pathogen' named entity 'respiratory disease' named entity 'strain' named entity 'Icelandic horse' named entity 'training' named entity 'causative' named entity 'diseased' named entity 'type 209' named entity 'animals' named entity 'Our' named entity 'demonstrate' named entity 'epidemic' named entity 'clones' named entity 'Horses' named entity 'Genomic' named entity 'S. zooepidemicus' named entity 'endemic' named entity 'infectious diseases' named entity 'S. zooepidemicus' named entity 'S. zooepidemicus' named entity 'Iceland' named entity 'S. zooepidemicus' named entity 'respiratory disease'

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