About: A Downward Trend of the Ratio of Influenza RNA Copy Number to Infectious Viral Titer in Hospitalized Influenza A-Infected Patients

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About: A Downward Trend of the Ratio of Influenza RNA Copy Number to Infectious Viral Titer in Hospitalized Influenza A-Infected Patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Downward Trend of the Ratio of Influenza RNA Copy Number to Infectious Viral Titer in Hospitalized Influenza A-Infected Patients
Creator	Ison, Michael Holmes, Mark Katz, Kevin Meeuws, Hanne Sadoff, Jerald Stuyver, Lieven Tolboom, Jeroen Dwyer, Dominic Mcgeer, Allison Weverling, Gerrit Haese, David Liesbeth, Van Wesenbeeck,
Source	Medline; PMC
abstract	Background. Efficacy endpoints in influenza clinical trials may include clinical symptoms and virological measurements, although virology cannot serve as the primary endpoint. We investigated the relationship between influenza A RNA copy number and quantity of infectious viruses in hospitalized influenza patients. Methods. One hundred fifty influenza-infected, hospitalized patients were included in this prospective cohort study spanning the 2012–2013 influenza season. Daily nasopharyngeal samples were collected during hospitalization, and influenza A RNA copy number and infectious viral titer were monitored. Results. The decay rate for 50% tissue culture infectious dose (TCID(50)) was 0.51 ± 0.14 log(10) TCID(50)/mL per day, whereas the RNA copy number decreased at a rate of 0.41 ± 0.04 log(10) copies/mL per day (n = 433). The log ratio of the RNA copy number to the infectious viral titer within patient changes significantly with −0.25 ± 0.09 units per day (P = .0069). For a 12-day observation period, the decay corresponds to a decline of this ratio of 3 log influenza RNA copies. Conclusions. Influenza RNA copy number in nasal swabs is co-linear with culture, although the rate of decay of cell culture-based viral titers was faster than that observed with molecular methods. The study documented a clear decreasing log ratio of the RNA copy number to the infectious viral titer of the patients over time.
has issue date	2015-11-03(xsd:dateTime)
bibo:doi	10.1093/ofid/ofv166
bibo:pmid	26677457
has license	cc-by-nc-nd
sha1sum (hex)	87dcbcb15da36050308aca4284d842193d99cd6c
schema:url	https://doi.org/10.1093/ofid/ofv166
resource representing a document's title	A Downward Trend of the Ratio of Influenza RNA Copy Number to Infectious Viral Titer in Hospitalized Influenza A-Infected Patients
has PubMed Central identifier	PMC4680923
has PubMed identifier	26677457
schema:publication	Open Forum Infect Dis
resource representing a document's body	covid:87dcbcb15da36050308aca4284d842193d99cd6c#body_text
is schema:about of	named entity 'VIROLOGY' named entity 'COPY NUMBER' named entity 'BACKGROUND' named entity 'PRIMARY ENDPOINT' named entity 'INFECTIOUS' named entity 'PATIENTS' named entity 'quantity' named entity 'Background' named entity 'TREND' named entity 'CLINICAL TRIALS' named entity 'VIROLOGICAL' named entity 'INFECTIOUS' named entity 'PATIENTS' named entity 'DOWNWARD' named entity 'COPY NUMBER' named entity 'RNA' named entity 'INFLUENZA' named entity 'VIRAL TITER' named entity 'HOSPITALIZED' named entity 'VIRUSES' named entity 'INFLUENZA A' named entity 'INFLUENZA' named entity 'INVESTIGATED' named entity 'MEASUREMENTS' named entity 'RNA' named entity 'QUANTITY' named entity 'INFLUENZA A' named entity 'INFECTED' named entity 'HOSPITALIZED' named entity 'SERVE' named entity 'INCLUDE' named entity 'EFFICACY' named entity 'RATIO' named entity 'CLINICAL SYMPTOMS' named entity 'RELATIONSHIP' named entity 'ENDPOINTS' covid:arg/87dcbcb15da36050308aca4284d842193d99cd6c named entity 'hospitalized' named entity 'primary endpoint' named entity 'clinical symptoms' named entity 'Viral Titer' named entity 'Copy Number' named entity 'Influenza' named entity 'coronavirus' named entity 'Westmead Hospital' named entity 'influenza' named entity 'epithelial cells' named entity 'limit of quantification' named entity 'viruses' named entity 'confidence interval' named entity 'RNA' named entity 'ILI' named entity 'antivirals' named entity 'infectivity' named entity 'pregnant women' named entity 'virus' named entity 'epidemics' named entity 'ILI' named entity '1.10' named entity 'viral RNA' named entity 'ICU' named entity 'Nasopharyngeal swabs' named entity '2.2' named entity 'RT-qPCR' named entity 'ICU' named entity 'Mount Sinai Hospital' named entity 'receiver operating characteristic analysis' named entity 'virus' named entity 'virus'

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