About: NK Cells in Mucosal Defense against Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	NK Cells in Mucosal Defense against Infection
Creator	Ivanova, Daria Krempels, Ryan Ryfe, Jennyfer Stephenson, David Weitzman, Kaitlyn Gigley, Jason
Source	Medline; PMC
abstract	Conventional natural killer cells (NK cells) provide continual surveillance for cancer and rapid responses to infection. They develop in the bone marrow, emerge as either NK precursor cells, immature, or mature cells, and disperse throughout the body. In the periphery NK cells provide critical defense against pathogens and cancer and are noted to develop features of adaptive immune responses. In the tightly regulated and dynamic mucosal tissues, they set up residency via unknown mechanisms and from sources that are yet to be defined. Once resident, they appear to have the ability to functionally mature dependent on the mucosal tissue microenvironment. Mucosal NK cells play a pivotal role in early protection through their cytolytic function and IFNγ production against bacteria, fungi, viruses, and parasitic infections. This review presents what is known about NK cell development and phenotypes of mucosal tissue resident conventional NK cells. The question of how they come to reside in their tissues and published data on their function against pathogens during mucosal infection are discussed. Dissecting major questions highlighted in this review will be important to the further understanding of NK cell homing and functional diversity and improve rational design of NK cell based therapies against mucosal infection.
has issue date	2014-08-14(xsd:dateTime)
bibo:doi	10.1155/2014/413982
bibo:pmid	25197644
has license	cc-by
sha1sum (hex)	8705d3a93c346b8b21e349c6263e680d844e7aea
schema:url	https://doi.org/10.1155/2014/413982
resource representing a document's title	NK Cells in Mucosal Defense against Infection
has PubMed Central identifier	PMC4150440
has PubMed identifier	25197644
schema:publication	Biomed Res Int
resource representing a document's body	covid:8705d3a93c346b8b21e349c6263e680d844e7aea#body_text
is schema:about of	named entity 'mucosal' named entity 'precursor cells' named entity 'periphery' named entity 'provide' named entity 'responses' named entity 'pivotal' named entity 'parasitic infections' named entity 'bacteria' named entity 'ABILITY TO' named entity 'FUNGI' named entity 'THEIR' named entity 'BONE MARROW' named entity 'PROTECTION' named entity 'DYNAMIC' named entity 'EMERGE' named entity 'DEFENSE' named entity 'DISPERSE' named entity 'PRODUCTION' named entity 'RAPID' named entity 'HOMING' named entity 'HOW' named entity 'TISSUES' named entity 'PROVIDE' named entity 'NK CELL' named entity 'REVIEW' named entity 'PRESENTS' named entity 'VIRUSES' named entity 'NK CELLS' named entity 'FUNCTIONAL DIVERSITY' named entity 'MECHANISMS' named entity 'IMMATURE' named entity 'CELL DEVELOPMENT' named entity 'KNOWN' named entity 'CELLS' named entity 'MAJOR' named entity 'NATURAL KILLER CELLS' named entity 'RESIDENCY' named entity 'INFECTION' named entity 'NK CELLS' named entity 'MUCOSAL' named entity 'QUESTION' named entity 'PUBLISHED' named entity 'IMPORTANT' named entity 'CRITICAL' named entity 'UNDERSTANDING' named entity 'BACTERIA' named entity 'RESIDE' named entity 'DATA' named entity 'MUCOSAL INFECTION' named entity 'REGULATED' named entity 'MUCOSAL' named entity 'NOTED' named entity 'SET UP' named entity 'SOURCES' named entity 'EITHER' named entity 'CONTINUAL' named entity 'RESIDENT' named entity 'HAVE' named entity 'ADAPTIVE IMMUNE RESPONSES' named entity 'MATURE' named entity 'RESPONSES' named entity 'COME' named entity 'ROLE' named entity 'FEATURES' named entity 'EARLY' named entity 'DISSECTING' named entity 'IFN' named entity 'WHAT' named entity 'APPEAR' named entity 'SURVEILLANCE FOR CANCER' named entity 'CONVENTIONAL' named entity 'PERIPHERY' named entity 'MICROENVIRONMENT' named entity 'BODY' named entity 'FUNCTION' named entity 'INFECTIONS'

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