About: SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

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About: SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB
Creator	Bartenschlager, Ralf Cortese, Mirko Lee, Ji-Young Neufeldt, Christopher Binder, Marco Boutros, Michael Burkart, Sandy Cerikan, Berati Debs, Bachir Frankish, Jamie Gendarme, Mathieu Halama, Niels Heigwer, Florian Joecks, Sebastian Merle, Uta Plociennikowska, Agnieszka Zander, David
Source	BioRxiv
abstract	SARS-CoV-2 is a novel virus that has rapidly spread, causing a global pandemic. In the majority of infected patients, SARS-CoV-2 leads to mild disease; however, in a significant proportion of infections, individuals develop severe symptoms that can lead to permanent lung damage or death. These severe cases are often associated with high levels of pro-inflammatory cytokines and low antiviral responses which can lead to systemic complications. We have evaluated transcriptional and cytokine secretion profiles from infected cell cultures and detected a distinct upregulation of inflammatory cytokines that parallels samples taken from infected patients. Building on these observations, we found a specific activation of NF-κB and a block of IRF3 nuclear translocation in SARS-CoV-2 infected cells. This NF-κB response is mediated by cGAS-STING activation and could be attenuated through STING targeting drugs. Our results show that SARS-CoV-2 curates a cGAS-STING mediated NF-κB driven inflammatory immune response in epithelial cells that likely contributes to inflammatory responses seen in patients and might be a target to suppress severe disease symptoms.
has issue date	2020-07-21(xsd:dateTime)
bibo:doi	10.1101/2020.07.21.212639
has license	biorxiv
sha1sum (hex)	86f6646d3ad9776d1b58fe1894f69df7534baf93
schema:url	https://doi.org/10.1101/2020.07.21.212639
resource representing a document's title	SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB
schema:publication	bioRxiv
resource representing a document's body	covid:86f6646d3ad9776d1b58fe1894f69df7534baf93#body_text
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