About: Effects of (L)-Cystine and (L)-Theanine Supplementation on the Common Cold: A Randomized, Double-Blind, and Placebo-Controlled Trial

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About: Effects of (L)-Cystine and (L)-Theanine Supplementation on the Common Cold: A Randomized, Double-Blind, and Placebo-Controlled Trial Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effects of (L)-Cystine and (L)-Theanine Supplementation on the Common Cold: A Randomized, Double-Blind, and Placebo-Controlled Trial
Creator	Akutsu, Masahisa Bannai, Makoto Hiraoka, Takenori Kurihara, Shigekazu Shibahara, Susumu Sukegawa, Eiji
Source	Medline; PMC
abstract	The common cold is one of the most frequent illnesses caused by viral infection. Recently, we have reported that oral administration of cystine and theanine (CT) to mice enhanced the humoral immune response associated with antibody production. Based on this mouse study, we investigated the effects of CT supplementation on the common cold in humans as a pilot study. A total of 176 healthy male volunteers were randomized to receive either placebo or CT (490 mg) tablets twice daily for 35 days. The incidence outcome was assessed using the definition in our laboratory based on questionnaires regarding cold symptoms. The incidence of subjects with colds during the trial was significantly lower in the CT group than in the placebo group, although the duration of the colds was not significantly different between the groups. These results suggest that CT supplementation may be useful for the prevention of the common cold.
has issue date	2010-05-12(xsd:dateTime)
bibo:doi	10.4061/2010/307475
bibo:pmid	22331996
has license	cc-by
sha1sum (hex)	8563a2aee8cce66a93317335e2ad07f6d06ed862
schema:url	https://doi.org/10.4061/2010/307475
resource representing a document's title	Effects of (L)-Cystine and (L)-Theanine Supplementation on the Common Cold: A Randomized, Double-Blind, and Placebo-Controlled Trial
has PubMed Central identifier	PMC3275984
has PubMed identifier	22331996
schema:publication	J Amino Acids
resource representing a document's body	covid:8563a2aee8cce66a93317335e2ad07f6d06ed862#body_text
is schema:about of	named entity 'incidence' named entity 'cystine' named entity 'antibody' named entity 'CYSTINE' named entity 'BASED' named entity 'VOLUNTEERS' named entity 'FREQUENT' named entity 'USEFUL' named entity 'ILLNESSES' named entity 'STUDY' named entity 'RANDOMIZED' named entity 'ANTIBODY PRODUCTION' named entity 'ASSESSED' named entity 'MAY BE' named entity 'common cold' named entity 'volunteers' named entity 'oral administration' named entity 'oral administration' named entity 'mice' named entity 'theanine' named entity 'placebo group' named entity 'humoral immune response' named entity 'cystine' named entity 'common cold' named entity 'saccharides' named entity 'infectious agent' named entity 'joint pain' named entity 'body temperature' named entity 'diarrhea' named entity 'malaise' named entity 'placebo' named entity 'placebo' named entity 'diarrhea' named entity 'febrile' named entity 'pilot study' named entity 'inflammatory mediator' named entity 'fever' named entity 'joint pain' named entity 'intercellular adhesion molecule-1' named entity 'common cold' named entity 'mice' named entity 'NF-κB' named entity 'anti-inflammatory effect' named entity 'cystine' named entity 'placebo' named entity 'placebo' named entity 'common cold' named entity 'clinician' named entity 'food ingredient' named entity 'ICAM-1' named entity 'antigen' named entity 'Japan' named entity 'Glycine' named entity 'glycine' named entity 'control subjects' named entity 'IRB' named entity 'fever' named entity 'symptom' named entity 'prophylactic' named entity 'immunosuppression' named entity 'meta-analysis' named entity 'Fisher's exact test' named entity 'food ingredient' named entity 'placebo' named entity 'joint pain' named entity 'common cold' named entity 'vomiting' named entity 'Body temperature' named entity 'symptom' named entity 'antigen' named entity 'dextrin' named entity 'N-acetylcysteine' named entity 'regression analysis' named entity 'runny nose' named entity 'fever' named entity 'Fisher's exact test'

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