About: Demineralized bone matrix in bone repair: History and use

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Demineralized bone matrix in bone repair: History and use
Creator	Gruskin, Elliott Doll, Bruce Futrell, F Hollinger, Jeffrey Schmitz, John
Source	Elsevier; Medline; PMC
abstract	Abstract Demineralized bone matrix (DBM) is an osteoconductive and osteoinductive commercial biomaterial and approved medical device used in bone defects with a long track record of clinical use in diverse forms. True to its name and as an acid-extracted organic matrix from human bone sources, DBM retains much of the proteinaceous components native to bone, with small amounts of calcium-based solids, inorganic phosphates and some trace cell debris. Many of DBM's proteinaceous components (e.g., growth factors) are known to be potent osteogenic agents. Commercially sourced as putty, paste, sheets and flexible pieces, DBM provides a degradable matrix facilitating endogenous release of these compounds to the bone wound sites where it is surgically placed to fill bone defects, inducing new bone formation and accelerating healing. Given DBM's long clinical track record and commercial accessibility in standard forms and sources, opportunities to further develop and validate DBM as a versatile bone biomaterial in orthopedic repair and regenerative medicine contexts are attractive.
has issue date	2012-09-30(xsd:dateTime)
bibo:doi	10.1016/j.addr.2012.06.008
bibo:pmid	22728914
has license	els-covid
sha1sum (hex)	842b3fa26ca61e4998ff14bb91785165f882ae7d
schema:url	https://doi.org/10.1016/j.addr.2012.06.008
resource representing a document's title	Demineralized bone matrix in bone repair: History and use
has PubMed Central identifier	PMC7103314
has PubMed identifier	22728914
schema:publication	Advanced Drug Delivery Reviews
resource representing a document's body	covid:842b3fa26ca61e4998ff14bb91785165f882ae7d#body_text
is schema:about of	named entity 'inducing' named entity 'retains' named entity 'bone' named entity 'long track' named entity 'track record' named entity 'inorganic' named entity 'surgically' named entity 'orthopedic' named entity 'track record' named entity 'DEMINERALIZED BONE MATRIX' named entity 'REGENERATIVE MEDICINE' named entity 'SHEETS' named entity 'WHERE' named entity 'TRUE' named entity 'LONG' named entity 'ENDOGENOUS' named entity 'CALCIUM' named entity 'BIOMATERIAL' named entity 'COMPONENTS' named entity 'STANDARD' named entity 'BASED' named entity 'SOLIDS' named entity 'APPROVED' named entity 'TRACE' named entity 'MEDICAL DEVICE USED' named entity 'AN ACID' named entity 'ORTHOPEDIC' named entity 'MUCH' named entity 'ACCESSIBILITY' named entity 'PLACED' named entity 'USE' named entity 'REPAIR' named entity 'PROTEINACEOUS' named entity 'FACILITATING' named entity 'GROWTH FACTORS' named entity '27S' named entity 'DBM' named entity 'RETAINS' named entity 'USE' named entity 'PASTE' named entity 'OSTEOGENIC' named entity 'SURGICALLY' named entity 'RECORD OF' named entity 'CLINICAL' named entity 'NEW BONE FORMATION' named entity 'HUMAN BONE' named entity 'KNOWN' named entity 'FORMS' named entity 'HISTORY' named entity 'GIVEN' named entity 'SOURCES' named entity 'TRACK' named entity 'FLEXIBLE' named entity 'NATIVE' named entity 'EXTRACTED' named entity 'BONE REPAIR' named entity 'CONTEXTS' named entity 'AMOUNTS' named entity 'THESE' named entity 'MATRIX' named entity 'HEALING' named entity 'RELEASE' named entity 'DIVERSE' named entity 'BONE' named entity 'ITS' named entity 'RECORD' named entity 'CELL DEBRIS' named entity 'DEMINERALIZED BONE MATRIX' named entity 'SITES' named entity 'INORGANIC PHOSPHATES' named entity 'WOUND' named entity 'ORGANIC' named entity 'SMALL' named entity 'COMMERCIAL' named entity 'ATTRACTIVE' named entity 'PROVIDES' named entity 'INDUCING'

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