About: Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients

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About: Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients
Creator	Martinez, Javier Guadalupe, Guzmán Guadalupe, Maria Aguirre, Maria Aguirre, Sonia Amely, Arencibia Caridad, María Delmis, Alvárez Dianelvys, Rosell Gainza, Gainza, Beatriz Garcia, Amely Garcia, Javier González Baez, Guelsy Martinez, Alfonso Muné Jiménez, Mayra Roque Arrieta, Rosmery Sierra Vazquez, Beatriz Sierra Vazquez, Sonia Simón, Simón, Rosell Tec, Tirado, Tirado, Guzmán Valdés Ramirez, Odalys Villalba, Montalvo
topic	covid:83abe391dabada8390f90dd45dd3237325e4a90e#this
Source	Elsevier
abstract	Upper respiratory tract is the primary site of SARS-CoV-2 replication. Releasing of pro and anti-inflammatory mediators plays an important role in the immunopathogenesis of Coronavirus Disease 2019 (COVID-19). The aim of this study was to evaluate the early inflammatory response in upper airway by measuring of IFN-γ, TGF-β1 and RANTES at mRNA level. Forty five SARS-CoV-2 infected patients were enrolled, whose were divided in two groups: asymptomatic and symptomatic. Twenty healthy persons, SARS-CoV-2 negative were included as controls. Higher IFN-γ expression was detected in SARS-CoV-2 infected patients in comparison with controls (p = 0,0393). IFN-γ expression was increased in symptomatic patients (p = 0,0165). TGF-β1 and RANTES expressions were lower in SARS-CoV-2 infected patients than controls (p < 0,0001; p = 0,0011, respectively). A significant correlation between IFN-γ and TGF-β1 was observed in SARS-CoV-2 asymptomatic patients (r = +0,61, p = 0,0014). The findings suggest that imbalance between IFN-γ and TGF-β1 expression could be an impact in clinical expression of SARS-CoV-2 infection.
has issue date	2020-08-29(xsd:dateTime)
bibo:doi	10.1016/j.clim.2020.108576
has license	els-covid
sha1sum (hex)	83abe391dabada8390f90dd45dd3237325e4a90e
schema:url	https://doi.org/10.1016/j.clim.2020.108576
resource representing a document's title	Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients
resource representing a document's body	covid:83abe391dabada8390f90dd45dd3237325e4a90e#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/83abe391dabada8390f90dd45dd3237325e4a90e
is schema:about of	named entity 'RANTES' named entity 'Please' named entity 'Fax' named entity 'infected' named entity 'patients' named entity 'RANTES' named entity 'SARS-CoV-2' named entity 'Clinical Immunology' named entity 'doi' named entity 'upper airway' named entity 'SARS-CoV-2' named entity 'upper airway' named entity 'cell mediated immunity' named entity 'dendritic cells' named entity 'growth factor' named entity 'qRT-PCR' named entity 'infection' named entity 'synergic' named entity 'epithelial cells' named entity 'humoral response' named entity 'infection' named entity 'positive and negative controls' named entity 'SARS-CoV-2' named entity 'RANTES' named entity 'TGF-β1' named entity 'isoform' named entity 'infection' named entity 'nasopharyngeal swabs' named entity 'rt-PCR' named entity 'cytokine' named entity 'SARS-CoV-2' named entity 'pathogenesis' named entity 'promoter region' named entity 'IFN gamma' named entity 'IFN-γ' named entity 'TGF-β1' named entity 'Pro-inflammatory cytokines' named entity 'TaqMan' named entity 'Correlation' named entity 'γδ T cell' named entity 'viral persistence' named entity 'initial phase' named entity 'critically ill' named entity 'Spearman correlation' named entity 'down-regulation' named entity 'Glyceraldehyde 3-phosphate dehydrogenase' named entity 'PCR reaction' named entity 'SARS-CoV-2' named entity 'Asymptomatic patients' named entity 'antibodies' named entity 'antigen recognition' named entity 'SARS-CoV-2' named entity 'TGF-β1' named entity 'SMAD4' named entity 'viral infection' named entity 'IFN-γ' named entity 'cytokine' named entity 'inflammation'

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