About: Macrophage colony-stimulating factor (CSF1) controls monocyte production and maturation and the steady-state size of the liver in pigs

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About: Macrophage colony-stimulating factor (CSF1) controls monocyte production and maturation and the steady-state size of the liver in pigs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Macrophage colony-stimulating factor (CSF1) controls monocyte production and maturation and the steady-state size of the liver in pigs
Creator	Lefevre, Lucas Magowan, Elizabeth Young, Rachel Clohisey, Sara Davis, Gemma Hume, David Lisowski, Zofia Mabbott, Neil Sauter, Kristin Summers, Kim Waddell, Lindsey Mcculloch, Mary Sauter, K Waddell, L
topic	covid:82ad828543f78e08f102305476b27173c62359fa#this
source	PMC
abstract	Macrophage colony-stimulating factor (CSF1) is an essential growth and differentiation factor for cells of the macrophage lineage. To explore the role of CSF1 in steady-state control of monocyte production and differentiation and tissue repair, we previously developed a bioactive protein with a longer half-life in circulation by fusing pig CSF1 with the Fc region of pig IgG1a. CSF1-Fc administration to pigs expanded progenitor pools in the marrow and selectively increased monocyte numbers and their expression of the maturation marker CD163. There was a rapid increase in the size of the liver, and extensive proliferation of hepatocytes associated with increased macrophage infiltration. Despite the large influx of macrophages, there was no evidence of liver injury and no increase in circulating liver enzymes. Microarray expression profiling of livers identified increased expression of macrophage markers, i.e., cytokines such as TNF, IL1, and IL6 known to influence hepatocyte proliferation, alongside cell cycle genes. The analysis also revealed selective enrichment of genes associated with portal, as opposed to centrilobular regions, as seen in hepatic regeneration. Combined with earlier data from the mouse, this study supports the existence of a CSF1-dependent feedback loop, linking macrophages of the liver with bone marrow and blood monocytes, to mediate homeostatic control of the size of the liver. The results also provide evidence of safety and efficacy for possible clinical applications of CSF1-Fc.
has issue date	2016-07-21(xsd:dateTime)
bibo:doi	10.1152/ajpgi.00116.2016
bibo:pmid	27445344
has license	cc-by
sha1sum (hex)	82ad828543f78e08f102305476b27173c62359fa
schema:url	https://doi.org/10.1152/ajpgi.00116.2016
resource representing a document's title	Macrophage colony-stimulating factor (CSF1) controls monocyte production and maturation and the steady-state size of the liver in pigs
has PubMed Central identifier	PMC5076001
has PubMed identifier	27445344
schema:publication	Am J Physiol Gastrointest Liver Physiol
resource representing a document's body	covid:82ad828543f78e08f102305476b27173c62359fa#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/82ad828543f78e08f102305476b27173c62359fa
is schema:about of	named entity 'LIVER' named entity 'revealed' named entity 'cells' named entity 'tissue' named entity 'expression' named entity 'expression profiling' named entity 'CSF1' named entity 'CSF1' named entity 'liver' named entity 'Licensed' named entity 'CC-BY 3.0' named entity 'MATURATION' named entity 'STEADY-STATE' named entity 'PROTEIN ' named entity 'MACROPHAGE COLONY-STIMULATING FACTOR' named entity 'OF LIVER INJURY' named entity 'ENRICHMENT' named entity 'RESULTS' named entity 'PIGS' named entity 'EXPRESSION PROFILING' named entity 'STEADY-STATE' named entity 'HEPATOCYTE PROLIFERATION' named entity 'LIVER' named entity 'GROWTH' named entity 'ADMINISTRATION' named entity 'ASSOCIATED WITH' named entity 'EARLIER' named entity 'ESSENTIAL' named entity 'POOLS' named entity 'INCREASE' named entity 'MACROPHAGE' named entity 'EFFICACY' named entity 'INCREASED EXPRESSION' named entity 'PROVIDE' named entity 'THEIR' named entity 'LICENSED' named entity 'SELECTIVE' named entity 'GENES' named entity 'MONOCYTE PRODUCTION' named entity 'IL6' named entity 'RAPID' named entity 'INFLUENCE' named entity 'REGION' named entity 'MARROW' named entity 'PIGS' named entity 'MACROPHAGE COLONY-STIMULATING FACTOR' named entity 'CREATIVE COMMONS' named entity 'MONOCYTE PRODUCTION' named entity 'ATTRIBUTION' named entity 'LARGE' named entity 'EXTENSIVE' named entity 'POSSIBLE' named entity 'BONE MARROW' named entity 'KNOWN' named entity 'HOMEOSTATIC' named entity 'SEEN' named entity 'CELLS' named entity 'ANALYSIS' named entity 'NO EVIDENCE OF' named entity 'PROLIFERATION' named entity 'MACROPHAGES' named entity 'CIRCULATING' named entity 'DIFFERENTIATION' named entity 'BLOOD MONOCYTES' named entity 'MACROPHAGE INFILTRATION' named entity 'REVEALED'

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