About: Covid-19: the renin–angiotensin system imbalance hypothesis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Covid-19: the renin–angiotensin system imbalance hypothesis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Covid-19: the renin–angiotensin system imbalance hypothesis
Creator	Simões, Ana Cordeiro, Thiago Costa, Larissa Lanza, Katharina Palmeira, Vitria Perez, Lucas Ribeiro, Victor
source	Medline; PMC
abstract	The emergency of SARS-CoV-2 in China started a novel challenge to the scientific community. As the virus turns pandemic, scientists try to map the cellular mechanisms and pathways of SARS-CoV-2 related to the pathogenesis of Coronavirus Disease 2019 (Covid-19). After transmembrane angiotensin-converting enzyme 2 (ACE2) has been found to be SARS-CoV-2 receptor, we hypothesized an immune-hematological mechanism for Covid-19 based on renin–angiotensin system (RAS) imbalance to explain clinical, laboratory and imaging findings on disease course. We believe that exaggerated activation of ACE/Angiotensin II (Ang II)/Angiotensin Type 1 (AT1) receptor RAS axis in line with reduction of ACE2/Angiotensin-(1-7)/Mas receptor may exert a pivotal role in the pathogenesis of Covid-19. In this perspective, we discuss potential mechanisms and evidence on this hypothesis.
has issue date	2020-06-08(xsd:dateTime)
bibo:doi	10.1042/cs20200492
bibo:pmid	32507883
has license	cc-by-nc-nd
sha1sum (hex)	82479a55be6c160922b07cbeeef63e3a0c61159d
schema:url	https://doi.org/10.1042/cs20200492
resource representing a document's title	Covid-19: the renin–angiotensin system imbalance hypothesis
has PubMed Central identifier	PMC7276636
has PubMed identifier	32507883
schema:publication	Clin Sci (Lond)
resource representing a document's body	covid:82479a55be6c160922b07cbeeef63e3a0c61159d#body_text
is schema:about of	named entity 'RENIN-ANGIOTENSIN SYSTEM' named entity 'endothelial cells' named entity 'oxygen' named entity 'SARS-CoV' named entity 'ACE2' named entity 'ACE2' named entity 'dyspnea' named entity 'binding activity' named entity 'hemoglobin' named entity 'alveolar' named entity 'anti-fibrotic' named entity 'oxygen' named entity 'experimental study' named entity 'hyperoxia' named entity 'infection' named entity 'Covid' named entity 'arterial hypertension' named entity 'diabetic' named entity 'SARS' named entity 'CSS' named entity 'SARS-CoV' named entity 'endothelial dysfunction' named entity 'lung' named entity 'Virus' named entity 'hydrophobic' named entity 'ACE2' named entity 'cytokine storm syndrome' named entity 'Covid' named entity 'endothelial dysfunction' named entity 'ACE2' named entity 'Covid' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'hemophagocytic lymphohistiocytosis' named entity 'antioxidative' named entity 'ACE2' named entity 'mice models' named entity 'virus replication' named entity 'epidemiological' named entity 'lungs' named entity 'clinical findings' named entity 'adaptive immune response' named entity 'multiple organ dysfunction' named entity 'SARS-CoV' named entity 'cell receptors' named entity 'SARS-CoV-2' named entity 'Covid' named entity 'interleukins' named entity 'anti-inflammatory' named entity 'anti-inflammatory' named entity 'physiological' named entity 'ACEi' named entity 'NIH' named entity 'SARS-CoV' named entity 'ACE2' named entity 'pro-inflammatory cytokines' named entity 'ACE inhibitors' named entity 'Ang II' named entity 'SARS-CoV-2' named entity 'vasodilators' named entity 'lung' named entity 'human body' named entity 'cardiovascular diseases' named entity 'enzyme' named entity 'Covid-19' named entity 'alveolar' named entity 'pro-inflammatory' named entity 'Covid' named entity 'Ang II' named entity 'Covid' named entity 'Viral infections' named entity 'amino acid residues' named entity 'pathophysiological' named entity 'NF-KB' named entity 'epithelium'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software