About: Prevalence and Impact of Myocardial Injury in Patients Hospitalized with COVID-19 Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Prevalence and Impact of Myocardial Injury in Patients Hospitalized with COVID-19 Infection
Creator	Zhao, Shan Fayad, Zahi Fuster, Valentin Sinai, Mount Glicksberg, Benjamin Johnson, Kipp Narula, Jagat Lala, Anuradha Mancini, Donna Pinney, Sean Bagiella, Emilia Charney, Alexander Chaudhry, Fayzan De Freitas, Jessica Januzzi, James Levin, Matthew Mph, M Nadkarni, Girish Paranjpe, Ishan Russak, Adam Somani, Sulaiman Vaid, Akhil Richter, Felix Aj, Russak Bs, Glicksberg Bs, Ishan Chaudhry, Vaid De Freitas Bs, Jessica Dm, Mancini Freitas, De Jl, Januzzi Kw, Johnson Richter Phd, Felix Somani Bs, Sulaiman Sp, Pinney Van Vleck, Tielman Vleck, Tielman Vleck, Van Za, Fayad
Source	Elsevier; Medline; PMC
abstract	Abstract Background The degree of myocardial injury, as reflected by troponin elevation, and associated outcomes among US hospitalized patients with Coronavirus Disease 2019 (COVID-19) are unknown. Objectives To describe the degree of myocardial injury and associated outcomes in a large hospitalized cohort with laboratory-confirmed COVID-19. Methods Patients with COVID-19 admitted to one of five Mount Sinai Health System hospitals in New York City between February 27th and April 12th, 2020 with troponin-I (normal value <0.03ng/mL) measured within 24 hours of admission were included (n=2,736). Demographics, medical history, admission labs, and outcomes were captured from the hospitals’ EHR. Results The median age was 66.4 years, with 59.6% men. Cardiovascular disease (CVD) including coronary artery disease, atrial fibrillation, and heart failure, was more prevalent in patients with higher troponin concentrations, as were hypertension and diabetes. A total of 506 (18.5%) patients died during hospitalization. In all, 985 (36%) patients had elevated troponin concentrations. After adjusting for disease severity and relevant clinical factors, even small amounts of myocardial injury (e.g. troponin I 0.03-0.09ng/mL, n=455, 16.6%) were significantly associated with death (adjusted HR: 1.75, 95% CI 1.37-2.24; P<0.001) while greater amounts (e.g. troponin I>0.09 ng/dL, n=530, 19.4%) were significantly associated with higher risk (adjusted HR 3.03, 95% CI 2.42-3.80; P<0.001). Conclusions Myocardial injury is prevalent among patients hospitalized with COVID-19 however troponin concentrations were generally present at low levels. Patients with CVD are more likely to have myocardial injury than patients without CVD. Troponin elevation among patients hospitalized with COVID-19 is associated with higher risk of mortality.
has issue date	2020-06-08(xsd:dateTime)
bibo:doi	10.1016/j.jacc.2020.06.007
bibo:pmid	32517963
has license	els-covid
sha1sum (hex)	81edd9ed48306b64fe586df700b4aae124a4280e
schema:url	https://doi.org/10.1016/j.jacc.2020.06.007
resource representing a document's title	Prevalence and Impact of Myocardial Injury in Patients Hospitalized with COVID-19 Infection
has PubMed Central identifier	PMC7279721
has PubMed identifier	32517963
schema:publication	J Am Coll Cardiol
resource representing a document's body	covid:81edd9ed48306b64fe586df700b4aae124a4280e#body_text
is schema:about of	named entity 'Results' named entity 'Sinai Health System' named entity 'total' named entity 'hospitalized' named entity 'hospitalization' named entity 'heart failure' named entity 'COVID-19' named entity 'patients' named entity 'Patients' named entity 'myocardial' named entity 'captured' named entity 'COVID-19' named entity 'elevation' named entity 'Patients' named entity 'mortality' named entity 'hospitals' named entity 'Patients' named entity 'Prevalence' named entity 'ELEVATION' named entity 'HOSPITALS' named entity 'HYPERTENSION' named entity 'injury' named entity 'risk' named entity 'troponin' named entity 'hospitalized' named entity 'greater' named entity '95% CI' named entity 'After' named entity 'risk' named entity 'levels' named entity 'injury' named entity 'large' named entity 'Injury' named entity 'troponin' named entity 'EHR' named entity 'myocardial injury' named entity 'COVID' named entity 'troponin' named entity 'troponin' named entity 'troponin' named entity 'myocardial injury' named entity 'Coronavirus Disease 2019' named entity 'CVD'

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