About: Evaluation of electrocardiographic ventricular repolarization variables in patients with newly diagnosed COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Evaluation of electrocardiographic ventricular repolarization variables in patients with newly diagnosed COVID-19
Creator	Aksan, Gökhan Arslan, Uğur Can Yontar, Osman Doğduş, Mustafa Erdoğan, Güney Gül, Sefa Günal, Özgür Prof Of Cardiology, Assoc Yenerçağ, Mustafa
source	Elsevier; Medline; PMC
abstract	INTRODUCTION: Coronavirus disease 2019 (COVID-19) is a newly recognized infectious disease that has spread rapidly. COVID-19 has been associated with a number of cardiovascular complications, including arrhythmias. The mechanism of ventricular arrhythmias in patients with COVID-19 is uncertain. The aim of the present study was to evaluate the ventricular repolarization by using the Tp-e interval, QT dispersion, Tp-e/QT ratio, and Tp-e/QTc ratio as candidate markers of ventricular arrhythmias in patients with newly diagnosed COVID-19. In addition, the relationship between the repolarization parameters and the CRP (C-reactive protein) was investigated. METHODS: 75 newly diagnosed COVID-19 patients, 75 age and sex matched healthy subjects were included in the study between 20th March 2020 and 10th April 2020. The risk of ventricular arrhythmias was evaluated by calculating the electrocardiographic Tp-e and QT interval, Tp-e dispersion, corrected QT(QTc), QT dispersion (QTd), corrected QTd, Tp-e/QT and Tp-e/QTc ratios. CRP values were also measured in patients with newly diagnosed COVID-19. RESULTS: Tp-e interval (80.7 ± 4.6 vs. 70.9 ± 4.8; p < .001), Tp-e / QT ratio (0.21 ± 0.01 vs. 0.19 ± 0.01; p < .001) and Tp-e/QTc ratio (0.19 ± 0.01 vs.0.17 ± 0.01; p < .001) were significantly higher in patients with newly diagnosed COVID-19 than the control group. There was a significant positive correlation between Tp-e interval, Tp-e/QTc ratio and CRP in patients with newly diagnosed COVID-19 (rs = 0.332, p = .005, rs = 0.397, p < .001 consecutively). During their treatment with hydroxychloroquine (HCQ), azithromycin and favipiravir, ventricular tachycardia episodes were observed in in two COVID-19 patients during their hospitalization in the intensive care unit. CONCLUSION: Our study showed for the first time in literature that the Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio, which are evaluated electrocardiographically in patients with newly diagnosed COVID-19, were prolonged compared with normal healthy individuals. A positive correlation was determined between repolarization parameters and CRP. We believe that pre-treatment evaluation of repolarization parameters in newly diagnosed COVID-19 would be beneficial for predicting ventricular arrhythmia risk.
has issue date	2020-07-21(xsd:dateTime)
bibo:doi	10.1016/j.jelectrocard.2020.07.005
bibo:pmid	32731139
has license	no-cc
sha1sum (hex)	8057dee79e1f00d87f3d9c5c416df9865ed39290
schema:url	https://doi.org/10.1016/j.jelectrocard.2020.07.005
resource representing a document's title	Evaluation of electrocardiographic ventricular repolarization variables in patients with newly diagnosed COVID-19
has PubMed Central identifier	PMC7373019
has PubMed identifier	32731139
schema:publication	J Electrocardiol
resource representing a document's body	covid:8057dee79e1f00d87f3d9c5c416df9865ed39290#body_text
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