About: The physiology and pharmacology of singlet oxygen

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The physiology and pharmacology of singlet oxygen
Creator	Stief, Thomas
Source	Elsevier; Medline; PMC
abstract	Abstract Reactive oxygen species (ROS) are generated by many different cells. Singlet oxygen (1 O 2) and a reaction product of it, excited carbonyls (CO), are important ROS. 1 O 2 and CO are nonradicalic and emit light (one photon/molecule) when returning to ground state oxygen. Especially activated polymorphonuclear neutrophil granulocytes (PMN) produce large amounts of 1 O 2 . Via activation of the respiratory burst (NADPH oxidase and myeloperoxidase) they synthesize hypochlorite (NaOCl) and chloramines (in particular N-chlorotaurine). Chloramines are selective and stable chemical generators of 1 O 2 . In the human organism, 1 O 2 is both a signal and a weapon with therapeutic potency against very different pathogens, such as microbes, virus, cancer cells and thrombi. Chloramines at blood concentrations between 1 and 2mmol/L inactivate lipid enveloped virus and chloramines at blood concentrations below 0.5 mmol/L, i.e. at oxidant concentrations that do not affect thrombocytes or hemostasis factors, act antithrombotically by activation of the physiologic PMN mediated fibrinolysis; this thrombolysis is of selective nature, i.e. it does not impair the hemostasis system of the patient allowing the antithrombotic treatment in patients where the current risky thrombolytic treatment is contraindicated. The action of 1 O 2 might be compared to the signaling and destroying gunfire of soldiers directed against bandits at night, resulting in an autorecruitment of the physiological inflammatory response. Chloramines (such as the mild and untoxic oxidant chloramine T® (N-chloro-p-toluene-sulfonamide)) and their signaling and destroying reaction product 1 O 2 might be promising new therapeutic agents against a multitude of up to now refractory diseases.
has issue date	2003-04-30(xsd:dateTime)
bibo:doi	10.1016/s0306-9877(03)00026-4
bibo:pmid	12615524
has license	els-covid
sha1sum (hex)	7fe41c86dc4c8aa3c9c37bb6a0f2a6cb316feb59
schema:url	https://doi.org/10.1016/s0306-9877%2803%2900026-4
resource representing a document's title	The physiology and pharmacology of singlet oxygen
has PubMed Central identifier	PMC7157913
has PubMed identifier	12615524
schema:publication	Medical Hypotheses
resource representing a document's body	covid:7fe41c86dc4c8aa3c9c37bb6a0f2a6cb316feb59#body_text
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