About: Development of immunoglobulin G enzyme-linked immunosorbent assay for the serodiagnosis of severe acute respiratory syndrome

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About: Development of immunoglobulin G enzyme-linked immunosorbent assay for the serodiagnosis of severe acute respiratory syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Development of immunoglobulin G enzyme-linked immunosorbent assay for the serodiagnosis of severe acute respiratory syndrome
Creator	Hsueh, Po-Ren Kao, Chuan-Liang Huang, Li-Min Huang, Fu-Yuan Chang, Luan-Yin Lu, Chun-Yi Shao, Pei-Lan Chiang, Yu-Ping Lee, Chin-Yun Chang, Lung-Ji Huang, Hsiang-Yi Wu, T.-C
Source	Medline; PMC
abstract	Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel SARS-associated coronavirus (SARS-CoV). The clinical characteristics are high fever, rapidly progressive diffuse pneumonitis and respiratory distress. It is highly infectious through intimate contact or direct contact with infectious body fluids. Outbreaks within communities and hospitals have been reported. Development of rapid and reliable diagnostic tools is urgently needed. We developed an immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA), using whole virus antigen of SARS-CoV. Eighty-six serum samples collected from patients who were hospitalized for other causes were examined to determine the cut-off O.D. value. The cut-off O.D. value was defined as 0.175 by calculating the mean O.D. value of the 86 sera plus 3 standard deviations. To determine the sensitivity and specificity of the ELISA, 56 positive sera and 204 negative sera were tested. The sensitivity was 96.4% and the specificity was 100%. The results suggest that the IgG ELISA using whole virus antigen of SARS-CoV has a high sensitivity and specificity in detecting SARS IgG antibodies. This IgG ELISA is a powerful tool for serodiagnosis of SARS.
has issue date	2005-02-04(xsd:dateTime)
bibo:doi	10.1007/s11373-004-8184-6
bibo:pmid	15864739
has license	no-cc
sha1sum (hex)	7e37ec5126b04c1579991417309dcaa961e194a1
schema:url	https://doi.org/10.1007/s11373-004-8184-6
resource representing a document's title	Development of immunoglobulin G enzyme-linked immunosorbent assay for the serodiagnosis of severe acute respiratory syndrome
has PubMed Central identifier	PMC7088774
has PubMed identifier	15864739
schema:publication	J Biomed Sci
resource representing a document's body	covid:7e37ec5126b04c1579991417309dcaa961e194a1#body_text
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