About: Ethyl alcohol threshold test: a fast, reliable and affordable olfactory Assessment tool for COVID-19 patients

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About: Ethyl alcohol threshold test: a fast, reliable and affordable olfactory Assessment tool for COVID-19 patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ethyl alcohol threshold test: a fast, reliable and affordable olfactory Assessment tool for COVID-19 patients
Creator	Alobid, Isam Calvo-Henriquez, Christian Carlos, · Chiesa-Estomba, Carlos Fragola, Claudio Gabriel Martínez-Capoccioni, · García-Fernández, Alfredo Hugo Pérez-Freixo, · Ithzel, · Karkos, D Lechien, Jerome Maldonado-Alvarado, Byron Mariño-Sánchez, Franklin Maria Del Mar Martínez Ruiz-Coello, · Mayo-Yáñez, Miguel Mondragon-Rezola, Elisabeth Navarro, Andrés Ninchritz-Becerra, Elisabeth Petros, · Raimundo, · Rivero-Fernández, Irene Rivero-De-Aguilar, Alejandro Robson Capasso, · Rodriguez-Iglesias, Miguel Santamaría-Gadea, Alfonso Sanz-Rodriguez, Marta Saussez, Sven Schriever, Valentin Soriano-Reixach, María Villarreal, María
Source	Medline; PMC
abstract	OBJECTIVE: COVID-19 patients may present mild symptoms. The identification of paucisymptomatic patients is paramount in order to interrupt the transmission chain of the virus. Olfactory loss could be one of those early symptoms which might help in the diagnosis of COVID-19 patients. In this study, we aim to develop and validate a fast, inexpensive, reliable and easy-to-perform olfactory test for the screening of suspected COVID-19 patients. STUDY DESIGN: Phase I was a case–control study and Phase II a transversal descriptive study. SUBJECTS AND METHODS: Olfaction was assessed with the ethyl alcohol threshold test and symptoms with visual analogue scales. The study was designed in two phases: In Phase I, we compared confirmed COVID-19 patients and healthy controls. In Phase II, patients with suspected COVID-19 infection referred for testing were studied. RESULTS: 275 participants were included in Phase I, 135 in Phase II. The ROC curve showed an AUC of 0.749 in Phase I, 0.737 in Phase II. The cutoff value which offered the highest amount of correctly classified patients was ≥ 2 (10% alcohol) for all age intervals. The odds ratio was 8.19 in Phase I, 6.56 in Phase II with a 75% sensitivity. When cases report normal sense of smell (VAS < 4), it misdiagnoses 57.89% of patients detected by the alcohol threshold test. CONCLUSION: The olfactory loss assessed with the alcohol threshold test has shown high sensitivity and odds ratio in both patients with confirmed COVID-19 illness and participants with suspected SARS-CoV-2 infection.
has issue date	2020-06-24(xsd:dateTime)
bibo:doi	10.1007/s00405-020-06131-3
bibo:pmid	32583183
has license	no-cc
sha1sum (hex)	7dc84584b07c378fd3227dcc9f12dd041e930182
schema:url	https://doi.org/10.1007/s00405-020-06131-3
resource representing a document's title	Ethyl alcohol threshold test: a fast, reliable and affordable olfactory Assessment tool for COVID-19 patients
has PubMed Central identifier	PMC7312102
has PubMed identifier	32583183
schema:publication	Eur Arch Otorhinolaryngol
resource representing a document's body	covid:7dc84584b07c378fd3227dcc9f12dd041e930182#body_text
is schema:about of	named entity 'Subjects' named entity 'visual' named entity 'COVID-19' named entity 'Phase I' named entity 'screening' named entity 'ROC curve' named entity 'reliable' named entity 'The' named entity 'case-control study' named entity 'patients' named entity 'threshold' named entity 'study' named entity 'Assessment' named entity 'Phase II' named entity 'odds ratio' named entity 'patients' named entity 'The' named entity 'Phase I' named entity 'COVID-19' named entity 'order' named entity 'Phase II' named entity 'infection' named entity 'phases' named entity 'olfactory' named entity 'cutoff' named entity 'age' named entity 'The' named entity 'test' named entity 'studied' named entity 'Phase II' named entity 'COVID' named entity 'infection' named entity 'Study design' named entity 'alcohol' named entity 'ethyl alcohol' named entity 'odds ratio' named entity 'misdiagnoses' named entity 'infection' named entity 'COVID' named entity 'sense of smell' named entity 'Olfactory' named entity 'Oto-Rhino-Laryngology' named entity 'Ethyl alcohol' named entity 'olfactory' named entity 'patients' named entity 'anosmic' named entity 'infection' named entity 'hyposmia' named entity 'COVID-19 infection' named entity 'hyposmia' named entity 'SARS-CoV-2' named entity 'COVID'

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